Medicinal plants and natural products as neuroprotective agents in age-related macular degeneration  

作　　者：Francisco Bosch-Morell Victoria Villagrasa Teresa Ortega Nuria Acero Dolores Muñoz-Mingarro MEugenia González-Rosende Encarna Castillo MAmparo Sanahuja Pilar Soriano Isabel Martínez-Solís 

机构地区：[1]Biomedical Sciences Institute,Universidad Cardenal Herrera-CEU,CEU Universities,Alfara del Patriarca,Valencia,Spain [2]Department of Biomedical Sciences,Faculty of Health Sciences,Universidad Cardenal Herrera-CEU,CEU Universities,Alfara del Patriarca,Valencia,Spain [3]Department of Pharmacy,Faculty of Health Sciences,Universidad Cardenal Herrera-CEU,CEU Universities,Alfara del Patriarca,Valencia,Spain [4]Department of Pharmacology,Pharmacognosy and Botany,Universidad Complutense de Madrid,Madrid,Spain [5]Department of Pharmaceutical and Health Sciences,Faculty of Pharmacy,Universidad San Pablo-CEU,CEU Universities,Madrid,Spain [6]Department of Chemistry and Biochemistry,Faculty of Pharmacy,Universidad San Pablo-CEU,CEU Universities,Madrid,Spain [7]ICBiBE-Botanical Garden,University of Valencia,Valencia,Spain

出　　处：《Neural Regeneration Research》2020年第12期2207-2216,共10页中国神经再生研究（英文版）

摘　　要：The retina may suffer neurodegenerative damages,as other tissues of the central nervous system do,and serious eye diseases may develop.One of them is age-related macular degeneration,which causes progressive loss of vision due to retina degeneration.Treatment of age-related macular degeneration focuses on antioxidant agents and anti-vascular endothelial growth factor compounds,among others,that prevent/diminish oxidative stress and reduce neovascularisation respectively.The phytochemicals,medicinal plants and/or plant-diet supplements might be a useful adjunct in prevention or treatment of age-related macular degeneration owing to their antioxidant and anti-vascular endothelial growth factor properties.This review article presents the most investigated plants and natural products in relation to age-related macular degeneration,such as saffron,ginkgo,bilberry and blueberry,curcuma or turmeric,carotenoids,polyphenols,and vitamins C and E.This study provides up-to-date information on the effects,treatments,safety and efficiency of these phytotherapy products.

关 键 词：age-related macular degeneration BILBERRY BLUEBERRY CURCUMA carotenoids GINKGO polyphenols SAFFRON VITAMINS 

分 类 号：R276.7[医药卫生—中医五官科学]