Isoflavones and inflammatory bowel disease  

作　　者：Ze-Yu Wu Li-Xuan Sang Bing Chang 

机构地区：[1]Department of Gastroenterology,The First Affiliated Hospital of China Medical University,Shenyang 110001,Liaoning Province,China [2]Department of Geriatrics,The First Affiliated Hospital of China Medical University,Shenyang 110001,Liaoning Province,China

出　　处：《World Journal of Clinical Cases》2020年第11期2081-2091,共11页世界临床病例杂志

基　　金：Supported by Innovative Talent Support Program of the Institution of Higher Learning in Liaoning Province,No.2018-478;Innovative Talents of Science and Technology Support Program of Young and Middle People of Shenyang,No.RC170446.

摘　　要：Isoflavones constitute a class of plant hormones including genistein,daidzein,glycitein,formononetin,biochanin A,and irilone,and the major source of human intake is soybeans.Inflammatory bowel disease(IBD)is a chronic recurrent inflammatory disease including ulcerative colitis,Crohn’s disease,and indeterminate colitis,which seriously affects the quality of life of patients and has become a global health problem.Although the pathogenesis of IBD is not very clear,many factors are thought to be related to the occurrence and development of IBD such as genes,immunity,and intestinal flora.How to control IBD effectively for a long time is still a problem for gastroenterologists.Diet has an important effect on IBD.Patients with IBD should pay more attention to diet.To date,many studies have reported that isoflavones have both good and bad effects on IBD.Isoflavones have many activities such as regulating the inflammatory signal pathways and affecting intestinal barrier functions and gut flora.They can also act through estrogen receptors,as they have a similar structure to estrogen.Isoflavones are easy to get from diet for human.Whether they are valuable to be applied to the treatment of IBD is worth studying.This review summarizes the relationship between isoflavones and IBD.

关 键 词：ISOFLAVONE METABOLISM EFFECTS Inflammatory bowel disease STRUCTURE TREATMENT 

分 类 号：R574[医药卫生—消化系统]