我国部分地区婴儿人群梭状芽胞杆菌暴露水平调查  

A study on Clostridium spp. exposure level on infant population in some parts of China

作　　者：李颖[1] 李凤琴 江涛 刘翔[3] 雷高鹏[4] 陈玉贞[5] 吴玲玲[6] 薛成玉[7] 胡晓宁[8] 董银苹 LI Ying;LI Fengqin;JIANG Tao;LIU Xiang;LEI Gaopeng;CHEN Yuzhen;WU Lingling;XUE Chengyu;HU Xiaoning;DONG Yinping(Children’s Hospital Affiliated to Capital Institute of Pediatrics,Beijing 100020,China;National Health Commission Key Laboratory of Food Safety Risk Assessment,China National Center for Food Safety Risk Assessment,Beijing 100021,China;Ningxia Centers for Disease Control and Prevention,Ningxia Yinchuan 750004,China;Sichuan Centers for Disease Control and Prevention,Sichuan Chengdu 610041,China;Shandong Centers for Disease Control and Prevention,Shandong Jinan 250014,China;Henan Centers for Disease Control and Prevention,Henan Zhengzhou 450016,China;Heilongjiang Centers for Disease Control and Prevention,Heilongjiang Harbin 150030,China;Gansu Centers for Disease Control and Prevention,Gansu Lanzhou 730000,China)

机构地区：[1]首都儿科研究所附属儿童医院,北京100020 [2]国家食品安全风险评估中心国家卫生健康委员会食品安全风险评估重点实验室,北京100021 [3]宁夏回族自治区疾病预防控制中心,宁夏银川750004 [4]四川省疾病预防控制中心,四川成都610041 [5]山东省疾病预防控制中心,山东济南250014 [6]河南省疾病预防控制中心,河南郑州450016 [7]黑龙江省疾病预防控制中心,黑龙江哈尔滨150030 [8]甘肃省疾病预防控制中心,甘肃兰州730000

出　　处：《中国食品卫生杂志》2020年第2期165-170,共6页Chinese Journal of Food Hygiene

基　　金：国家自然科学基金青年基金项目(81402684)。

摘　　要：目的以人群调查研究方式对我国部分地区婴儿及婴儿配方粉中梭状芽胞杆菌污染水平进行分析,获得我国婴儿人群梭状芽胞杆菌暴露水平数据。方法在我国六个省(自治区)设点,调查婴儿人群的基本信息,并对相关人群的粪便标本以及食品、环境和所在地市售婴儿配方粉样品进行采集,对所有样品/标本进行梭状芽胞杆菌检测。结果本研究共调查婴儿501人。按照喂养方式分组,包括纯母乳喂养247人,混合/人工喂养254人。按照年龄分组,包括0~6月龄367人,7~12月龄134人。采集样品813份,其中246份样品/标本中分离出梭状芽胞杆菌246株,总检出率为30.3%(246/813),其中检出率较高的梭状芽胞杆菌分别为生胞梭菌(8.4%,68/813)、双酶梭菌(6.2%,50/813)和丁酸梭菌(4.6%,37/813);梭状芽胞杆菌分离率最高的为粪便标本(37.3%,187/501),之后依次为市售婴儿配方粉样品(22.3%,27/121)、环境样品(19.5%,25/128)和食品样品(11.1%,7/63);其中混合/人工喂养组检出率高于纯母乳喂养组,7~12月龄组检出率高于0~6月龄组,差异均有统计学意义(χ2=40.833,P<0.01;χ2=27.829,P<0.01)。结论我国部分地区婴儿食用的食品及生活的环境中梭状芽胞杆菌暴露水平较高。Objective A case-control study on Clostridium spp.contamination on infant population and infant formula powdered was carried out, the data on Clostridium spp. exposure in some parts of China was obtained. Methods Epidemiological information and samples were collected from 6 locations in 6 provinces in China. The isolation and identification, of Clostridium spp. were performed. Results Totally 501 infants were investigated. Among them, 247 were exclusive breastfeeding and 254 were mixed feeding. According to the month grouping, 367 were 0-6 months and 134 were 7-12 months. A total of 813 samples were collected. After testing, 246 strains of Clostridium spp. were obtained and the positive rate was 30.3%(246/813). C.sporogenes(8.4%,68/813), C.bifermentans(6.2%,50/813) and C.butyricum(4.6%,37/813) had the highest detection rate.37.3%(187/501) of the stool samples were Clostridium spp. positive, followed by 22.3%(27/121) of the infant formula powder, 19.5%(25/128) of the environmental swab and 11.1%(7/63) of the food samples. The detection rate of Clostridium spp. in mixed feeding group was significantly higher than that of breast-feeding group(χ2=40.833,P<0.01), and 7-12-month-old group was significantly higher than that of 0-6 months group(χ2=27.829,P<0.01). Conclusion There was a high exposure level of Clostridium spp. in food and environment in infant population in some parts of China.

关 键 词：婴儿 婴儿配方粉 梭状芽胞杆菌 生胞梭菌 丁酸梭菌 暴露水平 

分 类 号：R155[医药卫生—营养与食品卫生学]