磷脂对脂质体性能的影响评析  

Effect evaluation and analysis of phospholipids on liposomes properties

作　　者：宋范范[1] 章绍兵[1] 田少君[1] SONG Fanfan;ZHANG Shaobing;TIAN Shaojun(College of Food Science and Technology,Henan University of Technology,Zhengzhou 450001,China)

机构地区：[1]河南工业大学粮油食品学院,郑州450001

出　　处：《中国油脂》2020年第5期32-35,41,共5页China Oils and Fats

基　　金：国家自然科学基金项目(31671887)。

摘　　要：脂质体具有类似生物膜的双分子层结构,是一种很有潜力的载体输送体系,在食品、药品和化妆品领域有广泛的应用价值和广阔的发展前景。磷脂作为脂质体的重要构建膜材,其自身的结构(脂肪酸链长度及饱和度、表面电荷)、来源、浓度及氧化和水解程度均会对脂质体的性能产生影响。总结了磷脂对脂质体性能的影响,并明确了选择磷脂时需要考虑的因素,可为脂质体的制备和应用提供参考。As one of the great potential carrier delivery system,liposomes have a wide range of application value and broad development prospect in food,pharmaceutics and cosmetics industries due to its bilayer structures similar to cell membrane.As the major membrane materials of liposomes,the structure(length of fatty acid chain and saturated degree,surface charge),source,concentration and the degree of oxidation and hydrolysis of phospholipids have influences on the liposomes properties.The effects of phospholipids on the liposomes properties were summarized,and the factors to be considered in the selection of phospholipids were clarified to provide references for the preparation and application of liposomes.

关 键 词：磷脂 脂质体 载体输送体系 性能 

分 类 号：TS201.1[轻工技术与工程—食品科学] TQ645.9[轻工技术与工程—食品科学与工程]