儿童遗传性肌张力障碍的脑深部电刺激手术治疗  

Surgical treatment of deep brain stimulation for pediatric hereditary dystonia

作　　者：杨海波[1] 曹自强 包新华[3] 文泳欣 姚红新[1] Yang Haibo;Cao Ziqiang;Bao Xinhua;Wen Yongxin;Yao Hongxin(Department of Pediatric Surgery,Peking University First Hospital,Beijing 100034,China;Department of Endocrinology,Peking University First Hospital,Beijing 100034,China;Department of Pediatrics,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院小儿外科,100034 [2]北京大学第一医院内分泌科,100034 [3]北京大学第一医院儿科,100034

出　　处：《中华实用儿科临床杂志》2020年第9期662-666,共5页Chinese Journal of Applied Clinical Pediatrics

摘　　要：近30年来,随着功能神经外科学、神经电生理学和神经影像学的进步,应运而生的脑深部电刺激术(DBS)被认为是治疗运动障碍疾病领域发展最为迅速的一种新的治疗方法。许多运动障碍病患者经过DBS治疗后主要临床症状得到显著改善,甚至治疗后出现戏剧性的进步。由于DBS的微创特性、可逆性和可调节性等优点,其已越来越多地应用在儿童肌张力障碍的治疗中。遗传性肌张力障碍是儿童最常见的一组运动障碍疾病,多无有效的药物治疗方法。最近,国内外一些运动障碍性疾病中心开展了儿童遗传性肌张力障碍DBS外科手术治疗,并取得了一些令人鼓舞的成果。基于北京大学第一医院儿童运动障碍疾病多学科协作诊疗中心的经验,现主要讨论DBS对儿童遗传性肌张力障碍的治疗效果和儿童患者DBS治疗的主要流程。In the past 30 years,with the advancement of functional neurosurgery,neuroelectrophysiology and neuroimaging,deep brain stimulation(DBS),as a new tool for the treatment of dyskinesia,has been considered to have underwent the fastest development in this field.Many patients with dyskinesias have significantly improved their main clinical symptoms after treatment with DBS,some of the improvement are even dramatic.Due to its minimally invasive characteristics,reversibility and adjustability,DBS therapy has been increasingly used in the treatment of dystonia in children.Hereditary dystonia is the most common type of dyskinesia in children,and there is no effective treatment yet.Recently,some dyskinesia at home and abroad centers have carried out DBS treatment for pediatric hereditary dystonia and achieved some encouraging results.Now,the effect of DBS in the treatment of hereditary dystonia in children and the main process of DBS treatment were mainly discussed,and shared the experience based on the clinical practices of Multidisciplinary Collaborative Diagnosis and Treatment Center for Children′s Motor Disorders,Peking University First Hospital.

关 键 词：脑深部电刺激术 运动障碍 肌张力障碍 遗传性 

分 类 号：R748[医药卫生—神经病学与精神病学]