CD2AP在阿尔茨海默病发病进程中作用的研究进展  

Research advances on the role of CD2AP in the pathogenesis of Alzheimer’s disease

作　　者：张令梁 罗红 张弦[1] 参丹 张云武[1] Zhang Ling-liang;Luo Hong;Zhang Xian;Can Dan;Zhang Yun-wu(Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research,Institute of Neuroscience,School of Medicine,Xiamen University,Xiamen 361102,China)

机构地区：[1]厦门大学医学院神经科学研究所暨福建省神经退行性疾病及衰老研究重点实验室,厦门361102

出　　处：《阿尔茨海默病及相关病杂志》2020年第2期141-146,共6页Chinese Journal of Alzheimer's Disease and Related Disorders

基　　金：国家重点研发计划重大慢性非传染性基本防控研究专项项目(2016YFC1305903);国家重点研发计划主动健康和老龄化科技应对重点专项项目(2018YFC2000400);国家自然科学基金促进海峡两岸科技合作联合基金重点支持项目(U1705285);国家自然科学基金面上项目(81771377)。

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是一种最为常见的神经变性疾病,其主要病理特征包括由β-amyloid(Aβ)蛋白多肽聚集形成的淀粉样斑块和由微管结合蛋白Tau聚集形成的神经原纤维缠结。CD2AP(CD2-associated protein)作为一种适配器蛋白,与细胞内蛋白转运以及细胞骨架重塑密切相关。CD2AP被发现是AD的一个风险因子。目前的研究显示CD2AP能够影响Aβ的生成和沉积、以及参与介导Tau蛋白的神经毒性。此外,CD2AP对血脑屏障的完整性和突触囊泡的转运也有影响。进一步深入研究CD2AP与AD的关系,对于揭示AD发病的分子机制有着重大意义。Alzheimer’s disease(AD)is the most common neurodegenerative disease and has two major pathological hallmarks as senile plaques and neurofibrillary tangles that are composed of b-amyloid(Ab)peptides and hyperphosphorylated microtubule associated protein Tau,respectively.CD2AP(CD2-associated protein)is an adaptor protein and involved in intracellular protein trafficking and cytoskeletion reorganization.Recently CD2AP has been identified as a risk factor of AD.Current evidence suggests that CD2AP may affect Ab production and deposition and mediate Tau neurotoxicity.Moreover,CD2AP may modulate the integrity of the blood-brain barrier and the transport of synaptic vesicles.Further study on the role of CD2AP in AD may strengthen our understanding on the molecular mechanism underlying the pathogenesis of AD.

关 键 词：CD2AP 阿尔茨海默病 Β-AMYLOID TAU 

分 类 号：R741[医药卫生—神经病学与精神病学]