Innate lymphoid cells control signaling circuits to regulate tissue-specific immunity  

作　　者：Christoph S.N.Klose David Artis 

机构地区：[1]Department of Microbiology,Infectious Diseases and Immunology,Charite-Universitatsmedizin Berlin,12203 Berlin,Germany [2]Jill Roberts Institute for Research in Inflammatory Bowel Disease,Joan and Sanford I.Weill Department of Medicine,Department of Microbiology and Immunology,Weill Cornell Medicine,Cornell University,New York,NY 10021,USA

出　　处：《Cell Research》2020年第6期475-491,共17页细胞研究（英文版）

基　　金：The work was supported by grants from the German Research Foundation(DFG,KL 2963/2-1 and SPP1937-KL 2963/3-1 to C.S.N.K.);the European Research Council(ERCEA,ERC Starting Grant#803087 to C.S.N.K.);the National Institutes of Health(NIH,AI074878,AI095466,AI095608 and AI102942 to D.A.);the Burroughs Wellcome Fund(to D.A.);the Crohn's&Colitis Foundation of America(to D.A.);Cure for IBD(to D.A.);the Rosanne H.Silberman Foundation(to D.A.).

摘　　要：The multifaceted organization of the immune system involves not only patrolling lymphocytes that constantly monitor antigenpresenting cells in secondary lymphoid organs but also immune cells that establish permanent tissue-residency.The integration in the respective tissue and the adaption to the organ milieu enable tissue-resident cells to establish signaling circuits with parenchymal cells to coordinate immune responses and maintain tissue homeostasis.Innate lymphoid cells(ILCs)are tissueresident innate immune cells that have a similar functional diversity to T cells including lineage-specifying transcription factors that drive certain effector programs.Since their formal discovery 10 years ago,it has become clear that ILCs are present in almost every tissue but strongly enriched at barrier surfaces,where they regulate immunity to infection,chronic inflammation,and tissue maintenance.In this context,recent research has identified ILCs as key in orchestrating tissue homeostasis through their ability to sustain bidirectional interactions with epithelial cells,neurons,stromal cells,adipocytes,and many other tissue-resident cells.In this review,we provide a comprehensive discussion of recent studies that define the development and heterogeneity of ILC populations and their impact on innate and adaptive immunity.Further,we discuss emerging research on the influence of the nervous system,circadian rhythm,and developmental plasticity on ILC function.Uncovering the signaling circuits that control development and function of ILCs will provide an integrated view on how immune responses in tissues are synchronized with functional relevance far beyond the classical view of the role of the immune system in discrimination between self/non-self and host defense.

关 键 词：IMMUNITY LYMPHOID HOMEOSTASIS 

分 类 号：R392[医药卫生—免疫学]