Freezing the kinase signaling of breast cancer with transformable peptide nanoparticles  

作　　者：Di-Wei Zheng Xian-Zheng Zhang 

机构地区：[1]Key Laboratory of Biomedical Polymers of Ministry of Education&Department of Chemistry,Wuhan University,Wuhan 430072,China

出　　处：《Science China Chemistry》2020年第8期1021-1022,共2页中国科学（化学英文版）

摘　　要：Protein kinases have been recognized as dominant regulators of all aspects of tumor progression,including tumorigenesis,proliferation,invasion,and metastasis[1].During the activation of protein kinases,the binding of ligands(e.g.,epidermal growth factor,transforming growth factor-α,and amphiregulin)can cause dimerization,which promotes the cell growth and triggers a cascade of downstream signaling pathways.

关 键 词：INVASION METASTASIS BREAST 

分 类 号：R737.9[医药卫生—肿瘤]