Potential therapeutic effects of polyphenols in Parkinson's disease:in vivo and in vitro pre-clinical studies  

作　　者：Claudio Giuliano Silvia Cerri Fabio Blandini 

机构地区：[1]Laboratory of Cellular and Molecular Neurobiology,IRCCS Mondino Foundation,Pavia,Italy

出　　处：《Neural Regeneration Research》2021年第2期234-241,共8页中国神经再生研究（英文版）

摘　　要：Parkinson's disease is a neurodegenerative disorder characterized by a combination of severe motor and non-motor symptoms.Over the years,several factors have been discovered to play a role in the pathogenesis of this disease,in particular,neuroinflammation and oxidative stress.To date,the pharmacological treatments used in Parkinson's disease are exclusively symptomatic.For this reason,in recent years,the research has been directed towards the discovery and study of new natural molecules to develop potential neuroprotective therapies against Parkinson's disease.In this context,natural polyphenols have raised much attention for their important anti-inflammatory and antioxidant properties,but also for their ability to modulate protein misfolding.In this review,we propose to summarize the relevant in vivo and in vitro studies concerning the potential therapeutic role of natural polyphenols in Parkinson's disease.

关 键 词：ALPHA-SYNUCLEIN ANTI-INFLAMMATORY ANTIOXIDANTS natural molecules NEUROPROTECTION Parkinson's disease POLYPHENOLS syntomatic effect 

分 类 号：R742.5[医药卫生—神经病学与精神病学]