广西居民膳食中黄曲霉毒素暴露风险评估  

Dietary exposure assessment of aflatoxins of residents in Guangxi

作　　者：石萌萌[1] 梁江 赵鹏[1] 钟延旭[1] 蒋玉艳[1] SHI Mengmeng;LIANG Jiang;ZHAO Peng;ZHONG Yanxu;JIANG Yuyan(Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention,Guangxi Nanning 530028,China;China National Center for Food Safety Risk Assessment,Beijing 100022,China)

机构地区：[1]广西壮族自治区疾病预防控制中心,广西南宁530028 [2]国家食品安全风险评估中心,北京100022

出　　处：《中国食品卫生杂志》2020年第4期432-436,共5页Chinese Journal of Food Hygiene

基　　金：广西壮族自治区卫生厅自筹经费科研课题(Z20190215);广西医疗卫生适宜技术开发与推广应用项目(S2017068)。

摘　　要：目的评估广西居民膳食中黄曲霉毒素的暴露水平及潜在健康风险。方法利用2013—2017年广西食品安全风险监测黄曲霉毒素含量数据、2012年广西居民营养与健康状况调查数据,采用简单分布评估和暴露限值(MOE)方法计算膳食中黄曲霉毒素暴露水平和致癌风险。结果广西居民膳食中黄曲霉毒素B1(AFB1)的每日平均暴露量和高暴露量(P95)分别为10.38和25.49 ng/kg BW,其MOE值分别为16和7;通过膳食摄入黄曲霉毒素致原发性肝细胞癌(HCC)平均发病风险为0.37例/10万人,高暴露人群致HCC发病风险为0.92例/10万人。油脂类及其制品(主要是花生油)是居民膳食中AFB1暴露的主要来源,贡献率高达72.17%;假设严格执行限量标准情况下,AFB1平均暴露量降至5.13 ng/kg BW,降幅为50.58%。结论低年龄儿童和油脂类及其制品在控制广西居民膳食中黄曲霉毒素暴露水平和致癌发病风险中是不可忽视的重点人群和重点食品,应给予较高的关注度。Objective To evaluate the exposure of aflatoxins and their potential health risks of residents in Guangxi.Methods The concentration data of aflatoxins from food safety monitoring in Guangxi in 2013-2017 and the food consumption data from nutrition and health investigation in 2012 were obtained.Based on deterministic assessment model and margin of exposure(MOE),the dietary exposure to projected risks for liver cancer was calculated.Results The average dietary exposure and the highly exposure(P95)of aflatoxins B1(AFB1)were 10.38 and 25.49 ng/kg BW,respectively.The MOE values were 16 and 7,the average risk for hepatocellular carcinoma(HCC)was 0.37 cases/105 people,and the risk for HCC in highly exposed was 0.92 cases/105 people.It was indicated that the main dietary sources of AFB1 were vegetable oil(mainly peanut oil),which was contributed more than 72.17%.Assuming that the standard limit was strictly implemented,the average exposure of AFB1 was 5.13 ng/kg BW,with a 50.58%reduction.Conclusion It should be paid more attention to the potential health risks caused by dietary exposure of AFB1 of residents in Guangxi,especially the low age group and vegetable oils.

关 键 词：黄曲霉毒素 暴露 风险评估 

分 类 号：R155[医药卫生—营养与食品卫生学]