应用电子舌和感官评定方法考察孟鲁司特钠口崩片的掩味效果  

Taste-Masking Effect of Montelukast Sodium Orally Disintegrating Tablets Using Electronic Tongue Analysis and Human Sensory Evaluation Method

作　　者：何朝星[1] 杜宇坤 杨鑫 何函星 王晓晖[1] 杜青[1] 曹德英[1] HE Chao-xing;DU Yu-kun;YANG Xin;HE Han-xing;WANG Xiao-hui;DU Qing;CAO De-ying(Hebei Medical University,Shijiazhuang 050017,China;The First Hospital of Shijiazhuang City,Shijiazhuang 050011,China)

机构地区：[1]河北医科大学,石家庄050017 [2]石家庄市第一医院,石家庄050011

出　　处：《中国药学杂志》2020年第16期1354-1357,共4页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金项目资助(81773666)。

摘　　要：目的应用电子舌技术和受试者感官评定方法考察孟鲁司特钠口崩片的掩味效果,以确定最佳处方。方法设计5种含不同用量矫味剂的处方及不含矫味剂的对照处方,分别制成口崩片。用电子舌测定口崩片的味道,采用主成分分析法和线性判别分析法评价不同处方的差别,结合受试者感官评定,考察孟鲁司特钠口崩片的掩味效果。结果当处方中矫味剂总量为1.6 mg,其中甜味剂与芳香剂比例为5∶3时,口崩片的口味最佳。结论应用电子舌技术,结合感官评定方法,可用于口崩片掩味效果的评价,为确定最佳处方提供依据。OBJECTIVE To investigate the taste-masking effect of montelukast sodium orally disintegrating tablets using electronic tongue technology and human sensory evaluation and determine the optimum formulation.METHODS Orally disintegrating tablets were prepared with five different concentrations of flavoring agents or without flavoring agent.The tastes of those tablets were determined by electronic tongue,and principal component analysis and linear discriminant analysis were used to evaluate differences of different formulations.The taste-masking effect of the tablets was investigated combined with electronic tongue analysis and sensory evaluation of subjects.RESULTS The taste of orally disintegrating tablet was the best when the total amount of flavoring agent was 1.6 mg,and the ratio of sweetening agent to aromatic agent was 5∶3.CONCLUSION The combination of electronic tongue and human sensory assess can evaluate the taste-masking effect of orally disintegrating tablets and provide the basis for determining the optimum formulation.

关 键 词：孟鲁司特钠 口崩片 电子舌 感官评定 主成分分析 线性判别分析 

分 类 号：R944[医药卫生—药剂学]