水产蛋白源生物活性肽研究进展  

Research progress on bioactive peptides derived from fishery proteins:a review

作　　者：林善婷 胡晓[1] 李来好[1] 杨贤庆[1] 吴燕燕[1] 陈胜军[1] 赵永强[1] 李春生[1] 潘创 LIN Shanting;HU Xiao;LI Laihao;YANG Xianqing;WU Yanyan;CHEN Shengjun;ZHAO Yongqiang;LI Chunsheng;PAN Chuang(Key Laboratory of Aquatic Product Processing, Ministry of Agriculture and Rural Affairs, National Research and Development Center for Aquatic Product Processing, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510300, China;Wuxi Fishery College, Nanjing Agricultural University, Wuxi 214081, China)

机构地区：[1]中国水产科学研究院南海水产研究所,农业农村部水产品加工重点实验室,国家水产品加工技术研发中心,广东广州510300 [2]南京农业大学无锡渔业学院,江苏无锡214081

出　　处：《大连海洋大学学报》2020年第5期775-785,共11页Journal of Dalian Ocean University

基　　金：国家现代农业产业技术体系专项(CARS-46);广东省自然科学基金(2017A030313164);广东省科技创新战略专项(2018S0044);国家重点研发计划项目(2018YFD0901102);“扬帆计划”引进创新创业团队专项(2015YT02H109);广东省基础与应用基础研究基金(2019A1515011588);三亚崖州湾科技城管理局2020年度科技计划项目(SKJC-2020-02-013)。

摘　　要：中国拥有丰富的水产品加工副产物及低值的鱼、虾、贝、藻等水产资源,其中含有的蛋白是制备生物活性肽的重要原料。本文综述了近年来水产蛋白源生物活性肽的酶解制备、分离纯化和质谱鉴定方法等研究进展,对抗氧化肽、抗菌肽、降血压肽、抗癌/抗肿瘤肽、免疫调节肽及矿物离子结合活性肽等不同生物活性肽进行了功能分类,分析了肽链的结构特征(肽的分子量大小、氨基酸组成),并阐述了不同生物活性肽的作用机制,提出了水产蛋白源生物活性肽的应用前景及其需要进一步研究的方向。China has abundant by-products of fishery products processing and low-value aquatic resources including fish,shrimp,shellfish,and algae in which the protein is an important raw material for the preparation of bioactive peptides.This article summarizes the methods of enzymatic hydrolysis,purification and mass spectrometry identification of bioactive peptides from fishery proteins base on the related researches in recent years.Different bioactive peptides are functionally classified,into antioxidant peptides,antimicrobial peptides,antihypertensive peptides,anticancer/antitumor peptides,immunomodulatory peptides,and mineral ion-chelating peptides.The molecular mechanism of bioactive peptides was discussed from the structure of peptides including molecular weight and amino acid composition,and the application prospect of aquatic bioactive peptides and the further research were proposed.

关 键 词：水产 生物活性肽 生物活性 结构特征 作用机制 

分 类 号：S986.1[农业科学—捕捞与储运]