Current status of COVID-19 treatment:An opinion review  

作　　者：Sveva Di Franco Aniello Alfieri Stephen Petrou Giovanni Damiani Maria Beatrice Passavanti Maria Caterina Pace Sebastiano Leone Marco Fiore 

机构地区：[1]Department of Women,Child and General and Specialized Surgery,University of Campania“Luigi Vanvitelli”,Naples 80138,Italy [2]Department of Emergency Medicine,Good Samaritan Hospital Medical Center,New York,NY 11795,United States [3]Department of Biomedical,Surgical and Dental Sciences,University of Milan,Milan 20122,Italy [4]Clinical Dermatology,IRCCS Instituto Ortopedico Galeazzi,Milan 20122,Italy [5]Division of Infectious Diseases,“San Giuseppe Moscati”Hospital,Avellino 83100,Italy

出　　处：《World Journal of Virology》2020年第3期27-37,共11页世界病毒学杂志

摘　　要：The pandemic severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has garnered the attention of scientists worldwide in the search for an effective treatment while also focusing on vaccine development.Several drugs have been used for the management of coronavirus disease 2019(COVID-19),which has affected many hospitals and health centers worldwide.Statistically significant results are lacking on the effectiveness of the experimented drugs in reducing COVID-19 morbidity or mortality,as there are very few published randomized clinical trials.Despite this,the literature offers some material for study and reflection.This opinion review attempts to address three burning questions on COVID-19 treatment options.(1)What kind of studies are currently published or ongoing in the treatment of patients with COVID-19?(2)What drugs are currently described in the literature as options of treatment for patients affected by the infection?And(3)Are there specific clinical manifestations related to COVID-19 that can be treated with a customized and targeted therapy?By answering these questions,we wish to create a summary of current COVID-19 treatments and the anti-COVID-19 treatments proposed in the recent clinical trials developed in the last 3 mo,and to describe examples of clinical manifestations of the SARS-CoV-2 infection with a cause-related treatment.

关 键 词：Antiviral drugs Coronavirus COVID-19 SARS-CoV-2 TOCILIZUMAB ECULIZUMAB ENOXAPARIN Hydroxychloroquine Pandemic TREATMENT Opinion review 

分 类 号：R73[医药卫生—肿瘤]