miRNA参与益生菌调节肠道屏障功能的研究进展  

Recent Progress in Understanding the Involvement of miRNA in the Protective Effect of Probiotics on Intestinal Barrier Function

作　　者：李艾黎[1] 张欣[1] 李颖 杨佳杰 马向阳 贾新栋 杜鹏[1] LI Aili;ZHANG Xin;LI Ying;YANG Jiajie;MA Xiangyang;JIA Xindong;DU Peng(College of Food Science,Northeast Agricultural University,Harbin 150030,China)

机构地区：[1]东北农业大学食品学院,黑龙江哈尔滨150030

出　　处：《食品科学》2020年第19期318-326,共9页Food Science

基　　金：青藏高原生态畜产品加工提质增效关键技术研究与产品开发项目(2018YFD0502404)。

摘　　要：以往研究表明,定植于肠道的益生菌可通过激活肠道免疫、抑制肠上皮细胞异常凋亡、调节紧密连接蛋白等多种途径增强肠道屏障功能,从而有利于宿主健康。新近报道提示非蛋白编码小分子RNA(microRNA或miRNA)作为调控宿主基因表达的重要因子之一,不仅是肠道屏障稳态的监督者,也是肠道益生菌与宿主相互作用的重要纽带。本文就近年来国内外有关miRNA参与益生菌保护肠道屏障的研究进行综述,旨在从分子水平解析益生菌促进肠道健康的作用机制,为应用益生菌预防和治疗肠道疾病提供新的理论支撑。Previous studies have confirmed that probiotics colonizing the intestine can enhance intestinal barrier function by activating intestinal immunity,inhibiting abnormal apoptosis of intestinal epithelial cells,and regulating tight junction protein,thereby being beneficial to the health of the host.Latest studies demonstrate that as one of the important factors regulating host gene expression,non-protein-encoding small molecule RNA(microRNA or miRNA)is not only a monitor of intestinal barrier homeostasis,but also an important link between intestinal probiotics and the host.This article reviews the recent studies on the role of miRNA in probiotic protection of intestinal barrier function,and analyzes the mechanism of probiotics in promoting intestinal health at the molecular level,aiming to provide new theoretical support for the application of probiotics in the prevention and treatment of intestinal diseases.

关 键 词：MIRNA 益生菌 肠道屏障 

分 类 号：TS201.3[轻工技术与工程—食品科学]