Successful treatment of a high-risk nonseminomatous germ cell tumor using etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine: A case report  

作　　者：Jina Yun Sang W Lee Sung H Lim Se H Kim Chan K Kim Seong K Park 

机构地区：[1]Department of Internal Medicine,Division of Hematology-Oncology,Soonchunhyang University Bucheon Hospital,Soonchunhyang University School of Medicine,Bucheon 14584,South Korea [2]Department of Urology and Internal Medicine,Soonchunhyang University Bucheon Hospital,Soonchunhyang University School of Medicine,Bucheon 14584,South Korea

出　　处：《World Journal of Clinical Cases》2020年第21期5334-5340,共7页世界临床病例杂志

基　　金：Supported by the Soonchunhyang University Research Fund,No.20200011.

摘　　要：BACKGROUND Choriocarcinoma is an infrequent entity and the most aggressive subtype of germcell tumors.Because of early metastatic spread and rapid disease progression,choriocarcinoma patients display poor prognosis.Although etoposide,methotrexate,actinomycin D,cyclophosphamide,and vincristine(EMA-CO)regimen is widely used to treat gestational trophoblastic tumors in females,its role in treating male choriocarcinoma is seldom reported.CASE SUMMARY A 32-year-old man was diagnosed with burned-out primary germ cell tumors(GCT)with retroperitoneum,liver and lung metastases.Biopsy of the liver revealed pure choriocarcinoma.The patient received bleomycin,etoposide,and cisplatin chemotherapy.After two cycles of treatment,response evaluation revealed the mixed response.EMA-CO regimen was used in the second-line therapy.After eight cycles,the patient showed a potentially resectable state and thus,all residual masses were surgically removed.The patient was completely cured,and 10 years later,he is leading a healthy life without complications.CONCLUSION This paper is the first case of high-risk nonseminomatous GCT in a male patient to be successfully treated with the EMA-CO regimen.The EMA-CO regimen can be used actively in patients with high-risk nonseminomatous GCT.

关 键 词：Antineoplastic combined chemotherapy protocols CHORIOCARCINOMA Testicular neoplasms CYCLOPHOSPHAMIDE METHOTREXATE Case report 

分 类 号：R737.2[医药卫生—肿瘤]