基于靶标的抗艾滋病药物研究新进展  

Advances of Research on Target-based Anti-AIDS Drugs

作　　者：付志鹏 康东伟[1,2] 刘新泳 展鹏[1,2] FU Zhipeng;KANG Dongwei;LIU Xinyong;ZHAN Peng(Department of Medicinal Chemistry,Key Laboratory of Chemical Biology(Ministry of Education),School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China;China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province,Jinan 250012,China)

机构地区：[1]山东大学药学院药物化学研究所化学生物学教育部重点实验室,山东济南250012 [2]山东省中比抗病毒创新药物合作研究中心,山东济南250012

出　　处：《药学进展》2020年第9期681-697,共17页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金(No.81420108027,No.81573347);山东省重大科技创新工程(No.2019JZZY021011,No.2017CXGC1401)。

摘　　要：如何克服药物的耐药性和降低不良反应一直是抗艾滋病药物研究的重要任务。随着结构生物学和药物筛选技术的快速发展,抗艾滋病的新靶标及其抑制剂被不断发现,增加了治愈艾滋病的希望。通过综述近几年的相关研究,从新药研发的角度总结基于靶标的抗艾滋病药物最新研究进展,以期为抗艾滋病药物研发提供参考。Overcoming drug resistance and alleviating side effects have always been a hot topic in the research on anti-HIV agents.With the rapid development of structural biology and drug screening technology,new anti-AIDS targets and their inhibitors have been discovered one after another,which has increased the hope of curing AIDS.From the point of view of medicinal chemistry,this review summarizes current endeavors towards the discovery of new target-based anti-AIDS drugs,with an attempt to provide reference for their development.

关 键 词：艾滋病 耐药性 小分子抑制剂 药物靶标 药物设计 

分 类 号：R914[医药卫生—药物化学]