Brain-derived neurotrophic factor and its related enzymes and receptors play important roles after hypoxic-ischemic brain damage  

作　　者：Liu-Lin Xiong Jie Chen Ruo-Lan Du Jia Liu Yan-Jun Chen Mohammed Al Hawwas Xin-Fu Zhou Ting-Hua Wang Si-Jin Yang Xue Bai 

机构地区：[1]National Traditional Chinese Medicine Clinical Research Base and Western Medicine Translational Medicine Research Center,Department of Cardiovascular Disease,Affiliated Traditional Chinese Medicine Hospital,Southwest Medical University,Luzhou,Sichuan Province,China [2]Cinical and Health Sciences,University of South Australia,Adelaide,Australia [3]Animal Zoology Department,Institute of Neuroscience,Kunming Medical University,Kunming,Yunnan Province,China [4]Institute of Neurological Disease,Translational Neuroscience Center,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China

出　　处：《Neural Regeneration Research》2021年第8期1453-1459,共7页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No. 82001604 (to LLX);the Joint Subject of Southwest Medical University and Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University of China,No. 2018XYLH-004 (to LLX);the National Construction Project of Regional Chinese Medicine Treatment Centre of China,No. 2018205 (to XB);the National Construction Project of the Second Clinical Research Base of Chinese Medicine of China,No. 2018131 (to XB)。

摘　　要：Brain-derived neurotrophic factor(BDNF) regulates many neurological functions and plays a vital role during the recovery from central nervous system injuries. However, the changes in BDNF expression and associated factors following hypoxia-ischemia induced neonatal brain damage, and the significance of these changes are not fully understood. In the present study, a rat model of hypoxic-ischemic brain damage was established through the occlusion of the right common carotid artery, followed by 2 hours in a hypoxic-ischemic environment. Rats with hypoxic-ischemic brain damage presented deficits in both sensory and motor functions, and obvious pathological changes could be detected in brain tissues. The m RNA expression levels of BDNF and its processing enzymes and receptors(Furin, matrix metallopeptidase 9, tissuetype plasminogen activator, tyrosine Kinase receptor B, plasminogen activator inhibitor-1, and Sortilin) were upregulated in the ipsilateral hippocampus and cerebral cortex 6 hours after injury;however, the expression levels of these m RNAs were found to be downregulated in the contralateral hippocampus and cerebral cortex. These findings suggest that BDNF and its processing enzymes and receptors may play important roles in the pathogenesis and recovery from neonatal hypoxic-ischemic brain damage. This study was approved by the Animal Ethics Committee of the University of South Australia(approval No. U12-18) on July 30, 2018.

关 键 词：brain injury brain-derived neurotrophic factor ENZYME HYPOXIA-ISCHEMIA RECEPTORS recovery repair 

分 类 号：R743.3[医药卫生—神经病学与精神病学]