HYPOXIA-ISCHEMIA

作品数：41被引量：201H指数：9
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相关领域：医药卫生更多>>
相关作者：张玲妹张研孙凤艳马正良于常州更多>>
相关机构：江苏省麻醉医学研究所上海医科大学南京大学医学院附属鼓楼医院巴斯克大学更多>>
相关期刊：《Chinese Journal of Traumatology》《Cellular & Molecular Immunology》《Acta Pharmacologica Sinica》《International Journal of Ophthalmology(English edition)》更多>>
相关基金：国家自然科学基金广东省自然科学基金江苏省卫生厅科研基金更多>>
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PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated mitophagy
《Acta Pharmacologica Sinica》2024年第9期1809-1820,共12页Xiao-lu Jiang Zu-bin Zhang Chen-xi Feng Chen-jie Lin Hui Yang Lan-lan Tan Xin Ding Li-xiao Xu Gen Li Tao Pan Zheng-hong Qin Bin Sun Xing Feng Mei Li 
National Natural Science Foundation of China(82271405,82071379,82171703,82371719);Interdisciplinary Basic Frontier Innovation Program of Suzhou Medical College of Soochow University(YXY2304072);The Natural Science Foundation of the Jiangsu Higher Education Institutions of China(22KJB320021);Training Program Foundation for health talents of Gusu(GSWS2020052,GSWS2019049);Project of Suzhou Science and Technology Development Plan(SKY2021008,SYS2020154).
Hypoxia-ischemia(HI)is one of the main causes of neonatal brain injury.Mitophagy has been implicated in the degradation of damaged mitochondria and cell survival following neonatal brain HI injury.Pleckstrin homology-...
关键词：neonatal brain injury HYPOXIA-ISCHEMIA PHLDA1 MITOPHAGY FUNDC1 Mdivi-1 
Reperfusion after hypoxia-ischemia exacerbates brain injury with compensatory activation of the antiferroptosis system:based on a novel rat model被引量：3
《Neural Regeneration Research》2023年第10期2229-2236,共8页Tian-Lei Zhang Zhi-Wei Zhang Wei Lin Xin-Ru Lin Ke-Xin Lin Ming-Chu Fang Jiang-Hu Zhu Xiao-Ling Guo Zhen-Lang Lin 
supported by the National Natural Science Foundation of China,No.82271747(to ZLL);Medical and Health Science and Technology Program of Zhejiang Province of China,No.2023RC048(to WL)。
Hypoxic-ischemic encephalopathy,which predisposes to neonatal death and neurological sequelae,has a high morbidity,but there is still a lack of effective prevention and treatment in clinical practice.To better underst...
关键词：ferroptosis hypoxic-ischemic brain injury hypoxic-ischemic encephalopathy hypoxic-ischemic reperfusion brain injury mitochondria model proteomic analysis REPERFUSION Rice-Vannucci transmission electron microscopy 
Scutellarin attenuates microglia activation in experimentally induced hypoxia-ischemia brain damage by down-regulating miRNA-7036a
《Acta Biochimica et Biophysica Sinica》2023年第10期1685-1688,共4页Wenji Jia Yun Yuan Li Yang Chunyun Wu 
supported by the grants from the National Natural Science Foundation of China(No.81960223 to C.W.);Applied Basic Research Projects of Yunnan Province(No.202001AY070001-217 to W.J.).
Neonatal hypoxic-ischemic encephalopathy(HIE)is widely acknowledged to cause acute neonatal death and chronic neurological injury[1].Currently,there is no effective treatment for neonatal hypoxia-ischemia brain damage...
关键词：damage ISCHEMIA HIE 
Acupuncture on intrauterine growth restriction associated brain injury:case study including use of magnetic resonance imaging被引量：1
《Journal of Traditional Chinese Medicine》2023年第3期602-605,共4页XIN Zhixiong LI Jiyuan XU Yanni LING Jing JIANG Min YU Yutian 
Supported by National Natural Science Foundation of China:Mechanisms Studies of γ-frequency Auricular Electroacupuncture Facilitates APP/PS1 Mice Cognition via P2X7R/NLRP3/Caspase-1 Pathway(No.82104980);Beijing Municipal Administration of Hospitals Incubating Program:Mechanisms Studies of Auricular Electroacupuncture on Hypothalamic P2Y1R in the Regulating Body Weight of ob/ob Mice(No.PZ2022005);Youth Grant of Beijing Shijitan Hospital:Mechanisms Studies of Auricular Electroacupuncture on Hypothalamic P2Y1R in the Regulating Body Weight of db/db Mice(No.2021-q01)。
Brain injury due to intrauterine growth restriction(IUGR) is a thorny clinical problem that often leads to permanent neurological deficits such as cerebral palsy.Few practical therapies can treat an IUGR-associated br...
关键词：ACUPUNCTURE fetal growth retardation brain injuries HYPOXIA-ISCHEMIA BRAIN magnetic resonance imaging neuronal plasticity 
The critical role of the endolysosomal system in cerebral ischemia被引量：3
《Neural Regeneration Research》2023年第5期983-990,共8页Hui-Yi Zhang Ye Tian Han-Yan Shi Ya Cai Ying Xu 
supported the National Natural Science Foundation of China,No. 81970760 (to YT);the Natural Science Foundation of Liaoning Province,No. 2021-MS-201 (to YX);the 345 Talent Project of Shengjing Hospital of China Medical University,No. M0370 (to YT);the 345 Talent Project of Shengjing Hospital of China Medical University,No. M0395 (to YX)。
Cerebral ischemia is a serious disease that triggers sequential pathological mechanisms, leading to significant morbidity and mortality. Although most studies to date have typically focused on the lysosome, a single o...
关键词：AUTOPHAGY biodegradation brain injury chaperone-mediated autophagy endolysosomal system fusion HYPOXIA-ISCHEMIA brain mitophagy N-ethylmaleimide-sensitive protein TMEM175 
Monocytes in neonatal stroke and hypoxic-ischemic encephalopathy:Pathophysiological mechanisms and therapeutic possibilities被引量：1
《Neuroprotection》2023年第1期20-33,共14页Pedro M.Pimentel-Coelho 
Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq),Grant/Award Number:13757/2020-8;Fundação de AmparoàPesquisa do Estado do Rio de Janeiro(FAPERJ),Grant/Award Numbers:E-26/201.279/2021,E-26/203.227/2017。
Neonatal arterial ischemic stroke(NAIS)and neonatal hypoxic-ischemic encephalopathy(HIE)are common causes of neurological impairments in infants,for which treatment options are very limited.NAIS and HIE induce an inna...
关键词：bone marrow cerebral ischemia MICROGLIA monocyte-derived macrophages MONOCYTES neonatal brain injury neonatal hypoxia-ischemia perinatal stroke 
The delivery of miR-21a-5p by extracellular vesicles induces microglial polarization via the STAT3 pathway following hypoxia-ischemia in neonatal mice被引量：4
《Neural Regeneration Research》2022年第10期2238-2246,共9页Dan-Qing Xin Yi-Jing Zhao Ting-Ting Li Hong-Fei Ke Cheng-Cheng Gai Xiao-Fan Guo Wen-Qiang Chen De-Xiang Liu Zhen Wang 
supported by the National Natural Science Foundation of China,Nos.81873768,82072535,81671213(to ZW),81770436(to WQC);the National Key Project of Chronic Non-Communicable Disease of China,No.2016YFC1300403(to WQC).
Extracellular vesicles(EVs)from mesenchymal stromal cells(MSCs)have previously been shown to protect against brain injury caused by hypoxia-ischemia(HI).The neuroprotective effects have been found to relate to the ant...
关键词：extracellular vesicles HYPOXIA-ISCHEMIA mesenchymal stromal cells MICROGLIA miR-21a-5p NEUROINFLAMMATION oxygen-glucose deprivation STAT3 
L-Cysteine attenuates osteopontin-mediated neuroinflammation following hypoxia-ischemia insult in neonatal mice by inducing S-sulfhydration of Stat3被引量：1
《Acta Pharmacologica Sinica》2022年第7期1658-1669,共12页Ting-ting Li Dan-qing Xin Hong-fei Ke Xi-li Chu Yi-jing Zhao Shou-wei Yue De-xiang Liu Zhen Wang 
This work was supported by the National Natural Science Foundation of China(nos.82072535,81873768,and 81671213 to ZW,81772436 to SY);the Major Scientific and Technological Innovation Project in Shandong Province(2019JZZY011112 to SY).
We previously show that L-Cysteine administration significantly suppresses hypoxia-ischemia(HI)-induced neuroinflammation in neonatal mice through releasing H2S.In this study we conducted proteomics analysis to explor...
关键词：hypoxia-ischemia brain injury L-CYSTEINE NEUROINFLAMMATION OSTEOPONTIN S-sulfhydration proteomics 
Corrigendum: Offspring of rats with cerebral hypoxia-ischemia manifest cognitive dysfunction in learning and memory abilities
《Neural Regeneration Research》2022年第2期265-265,共1页
In“Offspring of rats with cerebral hypoxia-ischemia manifest cognitive dysfunction in learning and memory abilities”,which was published on pages 1662-1670,Issue 9,Volume 15 of Neural Regeneration Research(Xue et al...
关键词：CEREBRAL ischemia RATS 
Brain-derived neurotrophic factor and its related enzymes and receptors play important roles after hypoxic-ischemic brain damage被引量：16
《Neural Regeneration Research》2021年第8期1453-1459,共7页Liu-Lin Xiong Jie Chen Ruo-Lan Du Jia Liu Yan-Jun Chen Mohammed Al Hawwas Xin-Fu Zhou Ting-Hua Wang Si-Jin Yang Xue Bai 
supported by the National Natural Science Foundation of China,No. 82001604 (to LLX);the Joint Subject of Southwest Medical University and Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University of China,No. 2018XYLH-004 (to LLX);the National Construction Project of Regional Chinese Medicine Treatment Centre of China,No. 2018205 (to XB);the National Construction Project of the Second Clinical Research Base of Chinese Medicine of China,No. 2018131 (to XB)。
Brain-derived neurotrophic factor(BDNF) regulates many neurological functions and plays a vital role during the recovery from central nervous system injuries. However, the changes in BDNF expression and associated fac...
关键词：brain injury brain-derived neurotrophic factor ENZYME HYPOXIA-ISCHEMIA RECEPTORS recovery repair 
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