TLR2 and TLR4-mediated inflammation in Alzheimer's disease: self-defense or sabotage?  

作　　者：Mark L.Dallas Darius Widera 

机构地区：[1]Cellular Neuroscience,School of Pharmacy,University of Reading,Reading,UK [2]Stem Cell Biology and Regenerative Medicine Group,School of Pharmacy,University of Reading,Whiteknights campus,Reading,UK

出　　处：《Neural Regeneration Research》2021年第8期1552-1553,共2页中国神经再生研究（英文版）

摘　　要：Alzheimer's disease(AD) is an irreversible disease that leads to neurodegeneration.The underpinning mechanisms of neuronal cell death are a matter of ongoing debate regarding the impact of accumulation of the amyloid beta(Aβ)peptide and post-translation modifications of the tau protein.However,a growing area of research and one that may provide a more rigorous account of the early changes seen in Alzheimer's brains is inflammation.

关 键 词：ALZHEIMER AΒ TAU TLR2 TLR4 

分 类 号：R749.16[医药卫生—神经病学与精神病学]