The Role and Function of Ras-association domain family in Cancer:A Review  

作　　者：Mohammad Reza Zinatizadeh Seyed Ali Momeni Peyman Kheirandish Zarandi Ghanbar Mahmoodi Chalbatani Hassan Dana Hamid Reza Mirzaei Mohammad Esmaeil Akbari Seyed Rouhollah Miri 

机构地区：[1]Cancer Research Center,Shahid Beheshti University of Medical Sciences,Tehran,Iran [2]Cancer Research Center,Cancer Institute of Iran,Tehran University of Medical Science,Tehran,Iran [3]Uro-Oncology Research Center,Tehran University of Medical Sciences,Tehran,IR,Iran [4]Cancer Research Center,Shohadae Tajrish Hospital,Department of Radiation Oncology,Shahid Beheshti University of Medical Sciences,Tehran,Iran

出　　处：《Genes & Diseases》2019年第4期378-384,共7页基因与疾病（英文）

摘　　要：Ras gene mutation has been observed in more than 30%of cancers,and 90%of pancreatic,lung and colon cancers.Ras proteins(K-Ras,H-Ras,N-Ras)act as molecular switches which are activated by binding to GTP.They play a role in the cascade of cell process control(proliferation and cell division).In the inactive state,transforming GTP to GDP leads to the activation of GTpase in Ras gene.However,the mutation in Ras leads to the loss of internal GTPase activity and permanent activation of the protein.The activated Ras can promote the cell death or stop cell growth,which are facilitated by Ras-association domain family.Various studies have been conducted to determine the importance of losing RASSF proteins in Rasinduced tumors.This paper examines the role of Ras and RASSF proteins.In general,RASSF proteins can be used as a suitable means for targeting a large group of Ras-induced tumors.

关 键 词：CANCER COLON H-RAS K-RAS Lung N-RAS PANCREATIC 

分 类 号：R73[医药卫生—肿瘤]