Signaling pathways in osteogenesis and osteoclastogenesis:Lessons from cranial sutures and applications to regenerative medicine  

作　　者：Justin B.Maxhimer James P.Bradley Justine C.Lee 

机构地区：[1]Division of Plastic and Reconstructive Surgery,UCLA David Geffen School of Medicine,CA,USA [2]Division of Plastic and Reconstructive Surgery,Temple University/St.Christopher’s Hospital for Children,PA,USA [3]Division of Plastic and Reconstructive Surgery,Greater Los Angeles VA Healthcare System,USA

出　　处：《Genes & Diseases》2015年第1期57-68,共12页基因与疾病（英文）

基　　金：supported by the Jean Perkins Foundation(JCL)and the Plastic Surgery Foundation(JCL)(234813).

摘　　要：One of the simplest models for examining the interplay between bone formation and resorption is the junction between the cranial bones.Although only roughly a quarter of patients diagnosed with craniosynostosis have been linked to known genetic disturbances,the molecular mechanisms elucidated from these studies have provided basic knowledge of bone homeostasis.This work has translated to methods and advances in bone tissue engineering.In this review,we examine the current knowledge of cranial suture biology derived from human craniosynostosis syndromes and discuss its application to regenerative medicine.

关 键 词：CRANIOSYNOSTOSIS OPG OSTEOCLAST RANK RANKL Tissue engineering OSTEOGENESIS Signaling 

分 类 号：R73[医药卫生—肿瘤]