Anti-hyperglycemic effects of dihydromyricetin in streptozotocin-induced diabetic rats  

作　　者：Maojun Yao Hui Teng Qiyan Lv Huifang Gao Tengming Guo Yiwen Lin Sihai Gao Meihu Ma Lei Chen 

机构地区：[1]College of Chemistry and Chemical Engineering,Jishou University,Jishou,416000,China [2]College of Food Science,Fujian Agriculture and Forestry University,Fuzhou,Fujian 350002,China [3]National Research and Development Center for Egg Processing,College of Food Science and Technology,Huazhong Agricultural University,Wuhan,Hubei,430070,China [4]Department of Cardiothoracic and Vascular Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,430070,China [5]College of Food Science and Technology,Guangdong Ocean University,Zhanjiang 524025,China

出　　处：《Food Science and Human Wellness》2021年第2期155-162,共8页食品科学与人类健康（英文）

基　　金：the National Natural Science Foundation of China(NSFC,Grant No.31801459,31701520);Science and Technology General Projects of Fujian Province(2019J01393);Educational research project for young and middleaged teachers in Fujian Province(JT180116).

摘　　要：Dihydromyricetin(DHM),as a bioactive flavanonol compound,is mainly found in“Tengcha”(Ampelopsis grossedentata)cultivated in south of China.This study aimed to investigate the anti-hyperglycemic and antidyslipidemic activities of DHM using type 2 diabetes mellitus(T2D)rats,which was induced by feeding with high fat and fructose diet for 42 days and intraperitoneal administration of streptozocin.Forty-eight freshlyweaned rats were randomly assigned into the negative control(Blank),low dose(100 mg/kg),medium dose(200 mg/kg),high dose(400 mg/kg),and positive(40 mg/kg,met)groups.Fasting blood glucose and body weight were measured at weekly interval.Oral glucose tolerance tests were performed on days 42.The results revealed that DHM possessed significant antihyperglycaemic and antihyperinsulinemic effects.Moreover,after the DHM treatment,p-Akt and p-AMPK expression was upregulated,and glycogen synthase kinase-3β(GSK-3β)expression was downregulated,indicating that the potential anti-diabetic mechanism of DHM might be due to the regulation of the AMPK/Akt/GSK-3βsignaling pathway.

关 键 词：Dihy dromyricetin Type 2 diabetes HYPOLIPIDEMIC HYPOGLYCEMIC AMPK/Akt/GSK-3βsignaling pathway 

分 类 号：TS201.4[轻工技术与工程—食品科学]