酿酒酵母对木质纤维素水解液抑制物耐受性的研究进展  

Research progress on the tolerance of Saccharomyces cerevisiae to inhibitors of lignocellulose hydrolysate

作　　者：雷志鹏 孙晓仲 王撼宇 陈欢[1] 王刚[1] 张斯童[1] 陈光[1] 孙旸[1] LEI Zhipeng;SUN Xiaozhong;WANG Hanyu;CHEN Huan;WANG Gang;ZHANG Sitong;CHEN Guang;SUN Yang(Key Laboratory of Straw Biology and Utilization,Ministry of Education,College of Life Science,Jilin Agricultural University,Changchun 130118,China;Jilin Province Product Quality Supervision and Inspection Institute,Changchun 130022,China)

机构地区：[1]吉林农业大学生命科学学院秸秆生物学与利用教育部重点实验室,吉林长春130118 [2]吉林省产品质量监督检验院,吉林长春130022

出　　处：《中国酿造》2021年第4期1-5,共5页China Brewing

基　　金：吉林省科技发展计划(20170203009NY);吉林省科技发展计划(20180201067SF)。

摘　　要：在木质纤维素转化为燃料乙醇的过程中,预处理产生的多种抑制物对酿酒酵母产生毒害作用,抑制细胞内相关代谢关键酶的活性,影响细胞生长和发酵过程,降低发酵过程中糖的转化率。该文介绍了木质纤维素常用的三种预处理方式及在不同预处理过程中抑制物形成的规律和作用机制,对提高酿酒酵母耐受性的方法进行了综述,并展望了未来通过基因工程和代谢工程相互耦合共同提高酿酒酵母性能的研究趋势,为提高酿酒酵母抑制物耐受性和纤维素乙醇发酵效率提供参考和借鉴。In the process of lignocellulosic conversion into fuel ethanol,a variety of inhibitors produced by the pretreatment had toxic effects on Saccharomyces cerevisiae,which inhibited the activities of key enzymes related to metabolism in cells,affected cell growth and fermentation process,and reduced the conversion rate of sugar in the fermentation process.In this paper,three kinds of common pretreatment methods of lignocellulose were introduced,and the formation and mechanism of inhibitors in different pretreatment processes were introduced.The methods of improving the tolerance of S.cerevisiae were summarized,and the future research trend of improving the performance of S.cerevisiae through the coupling of genetic engineering and metabolic engineering was prospected,which could provide reference for improving the tolerance of S.cerevisiae to inhibitors and the efficiency of cellulose ethanol fermentation.

关 键 词：燃料乙醇 预处理 酿酒酵母 抑制物耐受性 

分 类 号：TQ920.1[轻工技术与工程—发酵工程]