单端孢霉烯族毒素生物脱毒技术研究进展  

Progress on Bio-detoxification Technology of Trichothecenes

作　　者：朱晓慧 陆启荣 胡嗣祎 王旭[1] ZHU Xiao-hui;LU Qi-rong;HU Si-yi;WANG Xu(National Reference Laboratory of Veterinary Drug Residues (Huazhong Agricultural University)/Key Laboratory of the Detection for Veterinary Drug Residues,Ministry of Agriculture and Rural Affairs/Laboratory of Quality&Safety Risk Assessment for Livestock and Poultry Products,Ministry of Agriculture and Rural Affairs/College of Veterinary Medicine,Huazhong Agricultural University,Wuhan,Hubei,430070,China)

机构地区：[1]国家兽药残留基准实验室(华中农业大学)/农业农村部兽药残留检测重点实验室/农业农村部畜禽产品质量安全风险评估实验室/华中农业大学动物医学院,湖北武汉430070

出　　处：《动物医学进展》2021年第5期108-113,共6页Progress In Veterinary Medicine

基　　金：国际(地区)合作研究培育项目(2662020DKPY020);国家自然科学基金项目(32072925)。

摘　　要：单端孢霉烯族毒素在粮食和饲料中污染严重,主要是T-2毒素和脱氧雪腐镰刀烯醇(DON)等,其毒性作用强,对人和动物产生严重危害。因此,单端孢霉烯族毒素的脱毒方式逐渐成为研究热点,尤其是生物脱毒。很多微生物被证实能够降解霉菌毒素,包括细菌、真菌和酵母菌,可将毒素降解成低毒或无毒的产物。论文以生物脱毒为出发点,从细菌、真菌和酵母菌三个角度概述了单端孢霉烯族毒素中T-2毒素和DON的脱毒研究现状,以期为后续开发并挖掘更加安全高效的生物脱毒方式提供参考。Trichothecenes toxins are seriously polluted in food and feed,mainly T-2 toxin and deoxynivalenol(DON),which have strong toxic effects and cause serious harm to humans and animals.Therefore,the detoxification method of trichothecenes has gradually become a research hotspot,especially biological detoxification.Many microorganisms have been proven to be able to degrade mycotoxins,including bacteria,fungi and yeasts,and can degrade toxins into low-or non-toxic products.The thesis focused on biological detoxification as a starting point,and summarized the current research status of the detoxification of T-2 toxin and DON in trichothecenes from the perspectives of bacteria,fungi,and yeasts in order to provide scientific basis for subsequent development of safer and more efficient biological detoxification methods.

关 键 词：霉菌毒素 单端孢霉烯族毒素 T-2毒素 DON 生物脱毒 微生物 

分 类 号：S859.81[农业科学—临床兽医学] S855.4[农业科学—兽医学]