A novel isoform of ATOH8 promotes the metastasis of breast cancer by regulating RhoC  

作　　者：Mengyao Xu Shan Huang Xiaoli Dong Yanan Chen Miao Li Wen Shi Guanwen Wang Chongbiao Huang Qiong Wang Yanhua Liu Peiqing Sun Shuang Yang Rong Xiang Antao Chang 

机构地区：[1]School of Medicine,Nankai University,Tianjin 300071,China [2]Department of Cancer Biology and Comprehensive Cancer Center,Wake Forest University Medical Center,Winston-Salem,NC 27157,USA [3]International Collaborative Innovation Center of Medicine,Nankai University,Tianjin 300071,China [4]Department of Pancreatic Cancer,Tianjin Medical University Cancer Institute and Hosp让al,National Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin 300060,China

出　　处：《Journal of Molecular Cell Biology》2021年第1期59-71,共13页分子细胞生物学报（英文版）

基　　金：This work was supported by the National Science Foundation for Young Scientists of China(81702994);International S&T Cooperation Program of China(2015DFA30420);We thank Dr Ralph A.Reisfeld from the Scripps Research In stitute for his valuable suggestions and for proof-readi ng this manuscript.

摘　　要：Metastases are the main cause of cancer-related mortality in breast cancer.Although significant progress has been made in the field of tumor metastasis,the exact molecular mechanisms involved in tumor metastasis are still unclear.Here,we report that ATOH8-V1,a novel isoform of ATOH8,is highly expressed in breast cancer and is a negative prognostic indicator of survival for patients.Forced expression of ATOH8-V1 dramatically enhances,while silencing of ATOH8-V1 decreases the metastasis of breast cancer cell lines.Moreover,ATOH8-V1 directly binds to the RhoC promoter and stimulates the expression of RhoC,which in turn enhances the metastasis of breast cancer.Altogether,our data demonstrate that ATOH8-V1 is a novel pro-metastatic factor that enhances cancer metastasis,suggesting that AT0H8-V1 is a potential therapeutic target for treatment of metastatic cancers.

关 键 词：breast cancer ATOH8 METASTASIS RHOC 

分 类 号：R73[医药卫生—肿瘤]