Calcium-Sensing Receptor of Immune Cells and Diseases  

作　　者：Wenxiu Liu Yutong Guo MM Yue Liu Jiaxing Sun Xinhua Yin 

机构地区：[1]Department of Cardiology,The First Affi liated Hospital of Harbin Medical University,Harbin,150001 Heilongjiang,China

出　　处：《Cardiovascular Innovations and Applications》2021年第2期257-266,共10页心血管创新与应用（英文）

基　　金：supported by the National Natural Science Foundation of China for Xinhua Yin and Wenxiu Liu(81370319 and 81700318);the China Postdoctoral Science Foundation for Wenxiu Liu(2018M631957);the Hei Long Jiang Postdoctoral Fund for Wenxiu Liu(LBH-Z17145);Doctor Funds of the First Affi liated Hospital of Harbin Medical University for Wenxiu Liu(201613007);the Innovation and Entrepreneurship Training Program for College Students of Harbin Medical University for Wenxiu Liu(201910226157).

摘　　要：Calcium-sensing receptor(CaSR),which was initially found in the parathyroid gland,is ubiquitously expressed and exerts specifi c functions in multiple cells,including immune cells.CaSR is functionally expressed on neutrophils,monocytes/macrophages,and T lymphocytes,but not B lymphocytes,and regulates cell functions,such as cytokine secretion,chemotaxis,phenotype switching,and ligand delivery.In these immune cells,CaSR is involved in the development of many diseases,such as sepsis,cryopyrin-associated periodic syndromes,rheumatism,myocardial infarction,diabetes,and peripheral artery disease.Since its discovery,it has been controversial whether CaSR is expressed and plays a role in immune cells.This article reviews current knowledge of the role of CaSR in immune cells.

关 键 词：Calcium-sensing receptor NEUTROPHIL MONOCYTE/MACROPHAGE T lymphocyte B lymphocyte 

分 类 号：R36[医药卫生—病理学]