from National Natural Science Foundation of China(82002635,82002636,and 82173593);Guangzhou Science and Technology Project(202102021227 and 202102020421);Shenzhen Municipal Commission of Science and Technology Innovation(JCYJ20220531093213030)。
The recurrence and metastasis of children with mediastinal neuroblastoma(NB)are also occurred after surgery,chemotherapy,or radiotherapy.Strategies targeting the tumor microenvironment have been reported to improve su...
supported by Zhejiang Provincial Natural Science Foundation of China(No.D19H300001).
Compressed blood and intratumoral lymphatic vessels induced by proliferated tumor cells and elevated interstitial fluid pressure produce regional hypoxic and necrotic region within tumors,which severely reduced the ac...
Although monocytes and macrophages are key mediators of the innate immune system,the focus has largely been on the role of the adaptive immune system in the context of human immunodeficiency virus(HIV)infection.Thus m...
supported by the National Natural Science Foundation of China for Xinhua Yin and Wenxiu Liu(81370319 and 81700318);the China Postdoctoral Science Foundation for Wenxiu Liu(2018M631957);the Hei Long Jiang Postdoctoral Fund for Wenxiu Liu(LBH-Z17145);Doctor Funds of the First Affi liated Hospital of Harbin Medical University for Wenxiu Liu(201613007);the Innovation and Entrepreneurship Training Program for College Students of Harbin Medical University for Wenxiu Liu(201910226157).
Calcium-sensing receptor(CaSR),which was initially found in the parathyroid gland,is ubiquitously expressed and exerts specifi c functions in multiple cells,including immune cells.CaSR is functionally expressed on neu...
Supported by National Natural Science Fund of China (No.81130062, 81403367);the National Key Technology R&D Program during the 12th Five-Year Plan Period(2014BAI10B06)。
OBJECTIVE: To study the mechanistic effects of Tiaobu Feishen therapy(TBFS) on inflammation induced by cigarette smoke extract(CSE) in a human monocyte/macrophage cell line.METHODS: The human monocyte/macrophage cell ...
supported by the National Natural Science Foundation of China(31972821,31772876);Zhejiang Provincial Natural Science Foundation of China(LZ18C190001);Scientific Innovation Team Project of Ningbo(2015C110018);K.C.Wong Magna Fund in Ningbo University。
Liver-expressed antimicrobial peptide 2(LEAP-2)is a cationic peptide that plays an important role in a host’s innate immune system.We previously demonstrated that mudskipper(Boleophthalmus pectinirostris)LEAP-2(BpLEA...
supported by the National Natural Science Foundation of China(31972821;31772876);the Program of Zhejiang Provincial Natural Science Foundation of China(LZ18C190001);Science and Technology Department of Zhejiang Province(LGN18C180002);Natural Science Foundation of Ningbo City(2018A610342);the K.C.Wong Magna Fund in Ningbo University。
Interleukin-34(IL-34)is a novel cytokine that plays an important role in innate immunity and inflammatory processes by binding to the colonystimulating factor-1 receptor(CSF-1R).However,information on the function of ...
supported by the National Natural Science Foundation of China(31772876);Zhejiang Provincial Natural Science Foundation of China(LZ18C190001);Scientific Innovation Team Project of Ningbo(2015C110018);K.C.Wong Magna Fund in Ningbo University
D-dopachrome tautomerase(DDT),a member of the macrophage migration inhibitory factor(MIF)protein superfamily,is a newly described cytokine with chemokine-like characteristics.However,research on fish DDT remains limit...
Supported by Otsuka Frankfurt Research Institute, the legal and financial sponsor for this clinical trial, Otsuka Pharmaceutical Europe Ltd. supported the realization of this paper
AIM: To investigate efficacy and safety for granulocyte, monocyte apheresis in a population of pediatric patients with ulcerative colitis.METHODS: The ADAPT study was a prospective, open-label, multicenter study in pe...
This work has been supported by the grants from the National Natural Science Foundation of China (91029703, 81072436 and 81273268), with project funding from Suzhou City (SWG0904, SZS201109), Priority Academic Program Development of Jiangsu Higher Education Institutions, Qing Lan Project of Jiangsu Province, Jiangsu Provincial Innovative Research Team and the Program for Changjiang Scholars and Innovative Research Team in University (IRT1075).
FTY720, an agonist for four of the five known sphingosine- 1-phosphate (SIP) receptors, has been reported to inhibit acute graft-versus-host disease (aGVHD). Because FTY720 functions through multiple SIP receptors...