Research advances on how metformin improves memory impairment in “chemobrain”  

作　　者：Ahmad Alhowail Sridevi Chigurupati 

机构地区：[1]Department of Pharmacology and Toxicology,College of Pharmacy,Qassim University,Buraidah,Kingdom of Saudi Arabia [2]Department of Medicinal Chemistry and Pharmacognosy,College of Pharmacy,Qassim University,Buraydah,Kingdom of Saudi Arabia

出　　处：《Neural Regeneration Research》2022年第1期15-19,共5页中国神经再生研究（英文版）

基　　金：This work was supported by the Deanship of Scientific Research,Qassim University。

摘　　要：Cognitive impairment caused by chemotherapy,referred to as“chemobrain,”is observed in approximately 70% of cancer survivors.However,it is not completely understood how chemotherapy induces cognitive dysfunction,and clinical treatment strategies for this problem are lacking.Metformin,used as a first-line treatment for type 2 diabetes mellitus,is reported to reduce the effects of chemobrain.Recently,several studies have examined the effect of metformin in rescuing chemobrain.This review discusses recent clinical/preclinical studies that addressed some mechanisms of chemobrain and evaluates the effect of metformin in rescuing chemobrain and its potential mechanisms of action.

关 键 词：behavioral task chemobrain CHEMOTHERAPY cognitive impairments INFLAMMATION memory impairment METFORMIN neuroprotective agent review 

分 类 号：R730.53[医药卫生—肿瘤] R749.1[医药卫生—临床医学]