Estrogens still represent an attractive therapeutic approach for Alzheimer’s disease  

作　　者：Elena Tamagno Michela Guglielmotto 

机构地区：[1]Department of Neuroscience,University of Torino,Torino,Italy(Tamagno E,Guglielmotto M)Neuroscience Institute of Cavalieri Ottolenghi Foundation(NICO),University of Torino,Torino,Italy

出　　处：《Neural Regeneration Research》2022年第1期93-94,共2页中国神经再生研究（英文版）

摘　　要：Alzheimer’s disease(AD)is a progressive neurodegenerative condition that goes f rom mild cogni t ive impai rment in prodromal disease to severely disabling deficits in advanced stages.The risk for AD development,as well as progression and severity,clearly differ between men and women(Pike,2017).Epidemiological studies have shown that there is a significantly increased prevalence in the development of AD in women compared to men,which is usually explained by the longer lifespan of women.This increased frequency may be due to the interplay between age and sex,in which genetic factors together with hormonal and metabolic patterns play a crucial role.Moreover,cognitive impairment has been confirmed to be greater in women than in men at the same stage of AD,likely due to reduced estrogen levels in postmenopausal women(Laws et al.,2016).

关 键 词：ALZHEIMER ATTRACTIVE THERAPEUTIC 

分 类 号：R749.16[医药卫生—神经病学与精神病学]