Pharmacological strategies for treating misfolded rhodopsinassociated autosomal dominant retinitis pigmentosa  

作　　者：Yibo Xi Yuanyuan Chen 

机构地区：[1]Department of Ophthalmology,University of Pittsburgh,Pittsburgh,PA,USA [2]Department of Pharmacology and Chemical Biology,University of Pittsburgh,Pittsburgh,PA,USA [3]McGowan Institute of Regenerative Medicine,University of Pittsburgh,Pittsburgh,PA,USA

出　　处：《Neural Regeneration Research》2022年第1期110-112,共3页中国神经再生研究（英文版）

基　　金：supported by the NIH Grants R01 EY030991 to YC and the P30 EY008098 to the Department of Ophthalmology at University of Pittsburgh,the Ear and Eye Foundation of Pittsburgh and an unrestricted grant from Research to Prevent Blindness,New York,NY,USA。

摘　　要：Mutations that cause protein misfolding are implicated in conditions such as retinitis pigmentosa(RP),Usher Syndrome,and myocilin associated primary open angle glaucoma.The aggregation and continuous degradation of a highly abundant misfolded protein add proteolytic load of the affected cells.The subtle balance of cellular homeostasis,once disrupted by an overwhelmed proteolytic system,will lead to cell death and tissue degeneration.

关 键 词：RETINITIS DEGENERATION HOMEOSTASIS 

分 类 号：R774.1[医药卫生—眼科]