薏苡仁油自纳米乳化体系的建立及体外释放  

Preparation and in Vitro Release of Self-nanoemulsifying Delivery System of Coix Seed Oil

作　　者：易醒[1] 李娟[1] 易孜成 罗俊溢 袁弋婷 夏小华[1] 肖小年[1] Yi Xing;Li Juan;Yi Zicheng;Luo Junyi;Yuan Yiting;Xia Xiaohua;Xiao Xiaonian(Sino-German Food Engineering Center,Nanchang University,Nanchang 330047;Sino-German Joint Research Institute,Nanchang University,Nanchang 330047)

机构地区：[1]南昌大学中德食品工程中心,南昌330047 [2]南昌大学中德联合研究院,南昌330047

出　　处：《中国食品学报》2021年第6期11-18,共8页Journal of Chinese Institute Of Food Science and Technology

基　　金：国家自然科学基金项目(31760459,31960455)。

摘　　要：利用伪三元相图及星点设计-效应面优化等方法构建薏苡仁油自纳米乳化体系(CSO-SNEDS),对其进行特性表征和体外释放研究。试验结果显示:该体系最优配方为Tween60/Span20/丙三醇/薏苡仁油,其中薏苡仁油质量分数为16.11%,复合表面活性剂(Tween60/Span20质量比=9∶1)与助表面活性剂(丙三醇)的比例为3.54。CSO-SNEDS外观为黄色澄清的液体,经稀释可形成均一稳定的纳米乳,平均粒径、多分散指数、ζ-电位分别为47.52 nm,0.188和-15.7 mV。CSO-SNEDS在人工胃液和人工肠液中的体外释放动力学均符合Ritger-Peppas方程,拟合系数分别为0.731和0.912,释放机制为Fick扩散。In this paper,a pseudo-ternary phase diagram and star point design-response surface optimization were used to prepare the coix seed oil self-nanoemulsifying delivery system(CSO-SNEDS),and the characterization and in vitro release studies of CSO-SNEDS were investigated.The results show that the optimal component of the formula is Tween60/Span20/glycerol/coix seed oil.Among them,the coix seed oil mass fraction was 16.11%,and the ratio of the composite surfactant(Tween60/Span20=9∶1)to cosurfactant(glycerol)is 3.54.The CSO-SNEDS is a clear,transparent liquid that appears yellow.After dilution,it can form a uniform and stable nanoemulsion.The average particle size,polydispersity index,andζ-potential are 47.52 nm,0.188,-15.7 mV,respectively.The in vitro release kinetics of CSO-SNEDS in artificial gastric fluid and artificial intestinal fluid complies with the Ritger-Peppas equation with fitting coefficients of 0.731 and 0.912,respectively.Both release mechanisms are consistent with Fickian diffusion.

关 键 词：薏苡仁油 伪三元相图 星点设计-效应面优化 自纳米乳化体系 体外释放 

分 类 号：TS201.2[轻工技术与工程—食品科学]