Advances in the Pathogenesis of Alzheimer’s Disease:Focusing on Tau-Mediated Neurodegeneration  

作　　者：Yale Duan Suzhen Dong Feng Gu Yinghe Hu Zheng Zhao 

机构地区：[1]Key Laboratory of Brain Functional Genomics,Ministry of Education,Shanghai Key Laboratory of Brain Functional Genomics,East China Normal University,3663 Zhongshan Road(N),Shanghai 200062,China [2]Shanghai Engineering Research Center for Molecular Therapeutics and New Drug Development,East China Normal University,Shanghai 200062,China

出　　处：《Translational Neurodegeneration》2012年第1期192-198,共7页转化神经变性病（英文）

基　　金：This work was supported by the grants from the National Natural Science Foundation of China(No.31171019,No.81173108,No.31000574 and No.31200820);the Opening Projects of Shanghai Key Laboratory of Brain Functional Genomics and Key Laboratory of Brain Functional Genomics(East China Normal University),Ministry of Education。

摘　　要：In addition to senile plaques and cerebral amyloid angiopathy,the hyperphosphorylation of tau protein and formation of intraneuronal neurofibrillary tangles(NFTs)represents another neuropathological hallmark in AD brain.Tau is a microtubule-associated protein and localizes predominantly in the axons of neurons with the primary function in maintaining microtubules stability.When the balance between tau phosphorylation and dephosphorylation is changed in favor of the former,tau is hyperphosphorylated and the level of the free tau fractions elevated.The hyperphosphorylation of tau protein and formation of NFTs represent a characteristic neuropathological feature in AD brain.We have discussed the role of Aβin AD in our previous review,this review focused on the recent advances in tau-mediated AD pathology,mainly including tau hyperphosphorylation,propagation of tau pathology and the relationship between tau and Aβ.

关 键 词：Alzheimer’s disease TAU A-BETA TAUOPATHY Tau hyperphosphorylation Intraneuronal neurofibrillary tangles 

分 类 号：R74[医药卫生—神经病学与精神病学]