Mitochondrial dysfunction in Parkinson’s disease  

作　　者：Qingsong Hu Guanghui Wang 

机构地区：[1]Laboratory of Molecular Neuropathology,Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences,Soochow University,Suzhou,Jiangsu 215021,China [2]The Second Affiliated Hospital of Soochow University,Soochow University,Suzhou,Jiangsu 215021,China

出　　处：《Translational Neurodegeneration》2016年第1期118-125,共8页转化神经变性病（英文）

基　　金：This work was supported by the National Basic Research Program of China(2012CB947602);the National Natural Sciences Foundation of China(No.31300887);Natural Science Foundation of Jiangsu Province(BK20130299);Suzhou Clinical Research Center of Neurological Disease(Szzx201503);Jiangsu Provincial Special Program of Medical Science(BL2014042).

摘　　要：Parkinson’s disease(PD)is the second most common neurodegenerative disease,which is characterized by loss of dopaminergic(DA)neurons in the substantia nigra pars compacta and the formation of Lewy bodies and Lewy neurites in surviving DA neurons in most cases.Although the cause of PD is still unclear,the remarkable advances have been made in understanding the possible causative mechanisms of PD pathogenesis.Numerous studies showed that dysfunction of mitochondria may play key roles in DA neuronal loss.Both genetic and environmental factors that are associated with PD contribute to mitochondrial dysfunction and PD pathogenesis.The induction of PD by neurotoxins that inhibit mitochondrial complex I provides direct evidence linking mitochondrial dysfunction to PD.Decrease of mitochondrial complex I activity is present in PD brain and in neurotoxin-or genetic factorinduced PD cellular and animal models.Moreover,PINK1 and parkin,two autosomal recessive PD gene products,have important roles in mitophagy,a cellular process to clear damaged mitochondria.PINK1 activates parkin to ubiquitinate outer mitochondrial membrane proteins to induce a selective degradation of damaged mitochondria by autophagy.In this review,we summarize the factors associated with PD and recent advances in understanding mitochondrial dysfunction in PD.

关 键 词：Parkinson’s disease NEURODEGENERATION Mitochondrial deficiency MPTP Mitochondrial complex I inhibitor MITOPHAGY 

分 类 号：R74[医药卫生—神经病学与精神病学]