New insights into the significance of the BCR repertoire in B-1 cell development and function  

作　　者：Xiaohui Wang Cong Ye Xiang Lin Kongyang Ma Fan Xiao Lingli Dong Liwei Lu 

机构地区：[1]Department of Pathology and Shenzhen Institute of Research and Innovation,The University of Hong Kong,Hong Kong,China [2]Department of Rheumatology and Immunology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China

出　　处：《Cellular & Molecular Immunology》2019年第9期772-773,共2页中国免疫学杂志（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(No.91842304 and 81771761);the Health and Medical Research Fund,the Food and Health Bureau,the Hong Kong SAR Government,China(No.17160832);the Hong Kong Croucher Foundation(260960116).

摘　　要：As an important player of innate immunity,B-1 cells have been characterized by natural antibody production and rapid immune response.Based on their expression or lack of CD5,B-1 cells are further separated into B-1a and B-1b subsets.1 Although extensive studies have demonstrated a pivotal role of conventional B cells in adaptive immunity,there is increasing evidence indicating the close associations of B-1a cells with self-reactivity,autoimmunity,infection,and even leukemia.2–4 Here,we describe recent advances that lead to a clearer understanding of B-1 cell development with a focus on new insights into the significance of the B-cell receptor(BCR)repertoire in B-1a cell biology and discuss the potential strategies for specific targeting of B-1a cells under pathological settings.

关 键 词：IMMUNITY INSIGHT FUNCTION 

分 类 号：R73[医药卫生—肿瘤]