Lectin from Crataeva tapia bark exerts antitumor,anti-inflammtory and analgesic activities  

作　　者：Regina M.S.ARAÚJO Antônio F.M.VAZ Jaciana S.AGUIAR Luana C.B.B.COELHO Patrícia M.G.PAIVA Ana M.M.MELO Teresinha G.SILVA Maria T.S.CORREIA 

机构地区：[1]Departamento de Bioquímica,Centro de Ciências Biológicas,Universidade Federal de Pernambuco(UFPE),Avenida Prof.Moraes Rego s/n,50.670420,Recife,PE,Brazil [2]Departamento de Antibióticos,Centro de Ciências Biológicas,Universidade Federal de Pernambuco(UFPE),Avenida Prof.Moraes Rego s/n,50.670420,Recife,PE,Brazil [3]Departamento de Biofísica,Centro de Ciências Biológicas,Universidade Federal de Pernambuco(UFPE),Avenida Prof.Moraes Rego s/n,50.670420,Recife,PE,Brazil

出　　处：《Natural Products and Bioprospecting》2011年第2期97-100,共4页应用天然产物（英文）

基　　金：This work was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq);The authors also wish to thank Ronaldo Celerino da Silva and Sílvia Rafaelli Ramos for their valuable technical assistance.

摘　　要：Crataeva tapia bark lectin was evaluated for its antitumor activity against sarcoma 180 in Swiss albino mice.The anti-inflammatory and analgesic properties were investigated in models of inflammation and nociception.The anti-inflammatory assay was induced by carrageenan induced peritonitis and the analgesic activity was induced by acetic acid-induced writhing response.The lectin presents low toxicity with a LD50 of 2,500 mg/kg body weight and significant antitumor activity causing inhibition of tumor growth.The lectin also promoted significant reduction(35.4%)in the number of neutrophil migration induced by carrageenan.Concerning its analgesic property,the lectin inhibits abdominal contractions induced by acetic acid.The current results revealed a lectin with significant antitumoral,anti-inflammatory and antinociceptive activities.Further investigations to unveil the exact mechanisms are needed.

关 键 词：Crataeva tapia LECTIN ANTITUMORAL anti-inflammatory ANTINOCICEPTIVE 

分 类 号：R73[医药卫生—肿瘤]