funded by the Korea Health Technology R&D Project through the Bio and Medical Technology Development Program of the National Research Foundation,supported by the Ministry of Science and ICT(RS-2023-00210847)and the Ministry of Education(RS-2024-00463331),Republic of Korea.
The discovery of glycosylated RNA molecules,known as glycoRNAs,introduces a novel dimension to cellular biology.This commentary explores the transformative findings surrounding glycoRNAs,emphasizing their unique roles...
supported by the Science&Technology Fundamental Resources Investigation Program(2022FY202200);the Science and Technology Major Project of Xizang(XZ2025);the Second Tibetan Plateau Scientific Expedition and Research(STEP)program(2024QZKK0200);the Survey of Wildlife Resources in Key Areas of Xizang(ZL202203601 and ZL202303601);the Youth Innovation Promotion Association,Chinese Academy of Sciences(Y2022032).
The Pan-Himalaya,known as the“Roof of the World”,forms a natural geographic unit covering the entire range of the Himalaya and the Hengduan Mountains in addition to Karakorum and the northeastern extreme of Hindu Ku...
supported by Biological Breeding-National Science and Technology Major Project(no.2023ZD04070,W.Z.);the National Key Research and Development Program,Ministry of Science and Technology of China(no.2022YFD1201802,W.Z.);the National Natural Science Foundation of China(no.32472499,W.Z.);the Pinduoduo-China Agricultural University Research Fund(no.PC2023A01005,Y.-L.P.).
Maize(Zea mays)is one of the most important crops in the world,but its yield and quality are seriously affected by diverse diseases.Identifying broad-spectrum resistance genes is crucial for developing effective strat...
supported by funding from the Swiss National Science Foundation(SNSF Grant No.310030-215237/1);the Schoenmakers-Müller Foundation,a research grant from Ono Pharmaceuticals,and the Cancer League of Basel(KlbB).Open access funding provided by University of Basel.
The overexpression of sialic acids on glycans,called hypersialylation,is a common alteration found in cancer cells.Sialylated glycans can enhance immune evasion by interacting with sialic acid-binding immunoglobulin-l...
supported by a grant from the National Natural Science Foundation of China to X.Zhang(32070693)。
In animal cells,the Golgi apparatus serves as the central hub of the endomembrane secretory pathway.It is responsible for the processing,modification,and sorting of proteins and lipids.The unique stacking and ribbon-l...
Lectins have chaperone-like activity with carbohydrate-binding sites,which are key in cellular homeostasis.However,the specific interactions between lectins and endoplasmic reticulum(ER)proteins during stress are uncl...
The authors thank the Genomics Shared Resource(GSR)core facility at the University of California,Davis Health,Dr.Clifford G Tepper,Stephanie Liu,Ryan Davis,for helping in performing spatial RNA sequencing,and William Amato for his assistance in the quantification of immunohistochemistry slides.This manuscript is supported by grants funded by the USA National Institutes of Health(NIH)T32 CA108459e15,R01CA222490,R50CA243787.BioRender was used to draw mice figures in schematic experimental design.
This study examines inhibiting galectin 1(Gal1)as a treatment option for hepatocellular carcinoma(HCC).Gal1 has immunosuppressive and cancer-promoting roles.Our data showed that Gal1 was highly expressed in human and ...
supported by the National Natural Science Foundation of China(82104072 and 82373802);the Guangzhou Municipal Science and Technology Project(202201010424)。
supported by IISER Tirupati and by an Early Career Research award from the Science and Engineering Research Board,Department of Science and Technology,Govt.of India(ECR/2016/001071)to E.R.K.K.D.acknowledges the CSIR-JRF fellowship and Bi-nationally supervised doctoral degree scholarship from DAAD(91730390)for her PhD.A.M.and A.P.G.acknowledge funding from IISER Tirupati for graduate studies.S.C.acknowledges funding from IISER Tirupati and the Ramalingaswami Re-entry Fellowship(BT/RLF/Re-entry/05/2018)Department of Biotechnology,Government of India.
Rapid climate change has led to enhanced soil salinity,one of the major determinants of land degradation,resulting in low agricultural productivity.This has a strong negative impact on food security and environmental ...
Background: Sugar moiety of macromolecules is today very well known for its implications in many biological recognition mechanisms including cell-cell, extracellular matrix-cell and/or bacteria-cell interactions. In t...