ANTINOCICEPTIVE

作品数:30被引量:34H指数:3
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相关领域:医药卫生更多>>
相关机构:河北医科大学三峡大学更多>>
相关期刊:《Chinese Journal of Integrative Medicine》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《Journal of Pharmacy and Pharmacology》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划更多>>
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Antinociceptive Effect of Ethanolic Extract of Codiaeum variegatum Leaves in Mice
《Pharmacology & Pharmacy》2024年第9期285-302,共18页Md. Asrafuzzaman Ambia Khatun Md. Abdul Mannan 
Background: Codiaeum variegatum, sometimes called garden croton, is a tropical plant in the Euphorbiaceae family. Historically used to cure various conditions, including intestinal infections, fever, ulcers, wounds, a...
关键词:Codiaeum variegatum EXTRACT PHYTOCHEMISTRY ANTINOCICEPTIVE 
Antinociceptive Effect of Methanol Extract of Diospyros malabarica (Desr.) Kostel Leaves in Mice
《Pharmacology & Pharmacy》2023年第9期388-406,共19页Md. Azim Uddin Ambia Khatun Md. Abdul Mannan 
Background: Diospyros malabarica (Desr.) Kostel, a small to medium-sized tree in the Ebenaceae family, is known as “Deshi Gab” in Bangladesh. Fever, diabetes, snake bite, diarrhea, biliousness, and ulcer ailments ar...
关键词:Diospyros malabarica EXTRACT ANTINOCICEPTIVE PAIN 
The Anti-parasitic Effect of Extract of Ceiba pentandra (L.) Gaertn Is Related to Its Anti-inflammatory, Analgesic and Anthelmintic Activities on Haemonchus contortus
《Clinical Complementary Medicine and Pharmacology》2023年第2期65-73,共9页Bogning Zangueu Calvin Alowanou Goue Géorcelin Belle Ebanda Kedi Phillipe Olounlade Abiodoun Pascal Magne Fongang Annie Laure Kojom Wanche Jacquy Joyce Nguemfo Edwige Laure Azebaze Anatole Guy Blaise Dongmo Alain Bertrand Hounzangbe-Adote Mawulé Sylvie 
Background:Ceiba pentandra is a medicinal plant used as alternative therapy to control parasitic nematodes in livestock.Objective:This study aims to investigate anti-parasitic effect of aqueous stem back extract of Ce...
关键词:ANTI-INFLAMMATORY ANTINOCICEPTIVE ANTHELMINTIC Ceiba pentandra Haemonchus contortus 
Quantitative Electrophysiological Evaluation of the Analgesic Efficacy of Two Lappaconitine Derivatives: A Window into Antinociceptive Drug Mechanisms
《Neuroscience Bulletin》2021年第11期1555-1569,共15页Guixiang Teng Fengrui Zhang Zhenjiang Li Chun Zhang Libo Zhang Lele Chen Tao Zhou Lupeng Yue Ji Zhang 
This work was supported by the National Natural Science Foundation of China(51873175);the Special Fund of Guiding Scientific and Technological Innovation and Development in Gansu Province,China(2019ZX-05).
Quantitative evaluation of analgesic efficacy improves understanding of the antinociceptive mechanisms of new analgesics and provides important guidance for their development.Lappaconitine(LA),a potent analgesic drug ...
关键词:ELECTROCORTICOGRAM Analgesic effect Lappaconitine derivatives Antinociceptive mechanisms Laser-evoked potentials 
Enhancement in antinociceptive and anti-inflammatory effects of tramadol by transdermal proniosome gel被引量:3
《Asian Journal of Pharmaceutical Sciences》2020年第6期786-796,共11页Jigar Shah Anroop B.Nair Hiral Shah Shery Jacob Tamer M.Shehata Mohamed Aly Morsy 
Oral therapy of tramadol,an opiate analgesic,undergoes extensive hepatic metabolism and requires frequent administration.Transdermal therapy by virtue can overcome these issues and can improve the efficacy and reduce ...
关键词:TRAMADOL Proniosomes Flux EDEMA PHARMACOKINETICS Rats 
Antinociceptive grayanane-derived diterpenoids from flowers of Rhododendron molle被引量:7
《Acta Pharmaceutica Sinica B》2020年第6期1073-1082,共10页Yong Li Yuxun Zhu Zhaoxin Zhang Li Li Yunbao Liu Jing Qu Shuanggang Ma Shishan Yu 
supported by grants from the National Natural Science Foundation of China(Nos.21572274 and 21732008);the CAMS Innovation Fund for Medical Sciences(No.2016-I2M1-010,China)
Twelve new grayanoids(1-12)along with five known compounds were isolated from flowers of Rhododendron molle.Their structures were fully characterized using a combination of spectroscopic analyses,computational calcula...
关键词:Rhododendron molle DITERPENOID Grayanane DIMERIC ANTINOCICEPTIVE ANALGESIC 
Morphine induces dysfunction of PINK1/Parkin-mediated mitophagy in spinal cord neurons implying involvement in antinociceptive tolerance被引量:2
《Journal of Molecular Cell Biology》2019年第12期1056-1068,共13页Hong Kong Chun-Yi Jiang Liang Hu Peng Teng Yan Zhang Xiu-Xiu Pan Xiao-Di Sun Wen-Tao Liu 
the National Natural Science Foundation of China(81870870 to C.-Y.J.,81202513,and 81471142);Natural Science Foundation for Young Scientists of Jiangsu Province(BK20161033);the Key Project of Nanjing Medical University Sciente and Technology Innovation Foundation(2017NJMUCX004).
The development of opioid-induced analgesic tolerance is a clinical challenge in long-term use for managing chronic pain. The mechanisms of morphine tolerance are poorly understood. Mitochondria-derived reactive oxyge...
关键词:MITOPHAGY PINK1 PARKIN ROS SQSTM1/p62 morphine tolerance 
DN-9: a multifunctional agonist of opioid and neuropeptide FF receptors that produces nontoleranceforming analgesia via peripheral opioid receptors in inflammatory and neuropathic pain models
《中国药理学与毒理学杂志》2018年第9期713-713,共1页XU Biao ZHANG Meng-na SHI Xue-rui ZHANG Run LI Ning FANG Quan 
National Natural Science Foundation of China(81673282;81273355).
OBJECTIVE Considerable effort has recently been directed at developing multifunctional opioid drugs as an alternative strategy to minimize the unwanted side effects of opioid analgesics.We recently developed a novel m...
关键词:OPIOID MULTIFUNCTIONAL drugs ANALGESIA ANTINOCICEPTIVE tolerance ABUSE properties 
Anti-inflammatory and antinociceptive activities of Rhipicephalus microplus saliva
《Asian Pacific Journal of Tropical Biomedicine》2018年第4期194-200,共7页DF.Buccini AA.Nunes GGO.Silva ON.Silva OL.Franco SE.Moreno 
supported by FUNDECT(Foundation for Support for the Development of Education,Science and Technology of the State of Mato Grosso do Sul);(FUNDECT/CAPES N°26/2014)Coordination for the Improvement of Higher Level Education Personnel(CAPES);National Council for Scientific and Technological Development(CNPq)
To evaluate the antinociceptive and anti-inflammatory activities and the toxic effects of Rlhipicephalus microplus saliva for elucidating the modulation mechanism between arthropod saliva and host.Methods:For saliva c...
关键词:Rhipicephalus microplus SALIVA TICK ANTINOCICEPTIVE ANTI-INFLAMMATORY 
Sedative and antinociceptive activities of two new sesquiterpenes isolated from Ricinus communis被引量:2
《Chinese Journal of Natural Medicines》2018年第3期225-230,共6页Umar Farooq Ajmal Khan Sadia Naz Abdur Rauf Haroon Khan Afsar Khan Irfan Ullah Syed Majid Bukhari 
financially supported by the Higher Education Commission of Pakistan(No.2003)
Two new sesquiterpenes, trivially named ricinusoids A(1) and ricinusoids B(2), were isolated from ethyl acetate fraction of Ricinus communis. The structures of new compounds were elucidated by detailed spectroscopic t...
关键词:Ricinus communis SESQUITERPENOIDS EUPHORBIACEAE Spectroscopic techniques Antinociceptive activity 
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