Autoimmune pancreatitis and pancreatic cancer:Epidemiological aspects and immunological considerations  

作　　者：Dimitri Poddighe 

机构地区：[1]Department of Medicine,School of Medicine,Nazarbayev University,Nur-Sultan 010000,Kazakhstan [2]Department of Pediatrics,National Research Institute for Maternal and Child Health(NRCMCH),University Medical Center(UMC)Nur-Sultan 010000,Kazakhstan

出　　处：《World Journal of Gastroenterology》2021年第25期3825-3836,共12页世界胃肠病学杂志（英文版）

摘　　要：Ordinary chronic pancreatitis is a well-known risk factor for pancreatic cancer,whereas such an association with autoimmune pancreatitis(AIP)is widely debated.Due to the rarity of the latter disorder,there are few specific clinical and epidemiological studies investigating the relation between AIP and pancreatic cancer,which do not seem to support it.However,these studies are affected by several limitations and,therefore,a link between AIP(and,specifically,type 1 AIP)and pancreatic cancer cannot be ruled out definitively on this basis.Moreover,several immunopathological aspects of type 1 AIP and,in general,immunoglobulin G4-related disease can create an immunological context that may impair the tumoral immunosurveillance and promote the pancreatic carcinogenesis and its progression.In detail,Th2 immunological dominance,type 2 macrophage polarization and basophil infiltration observed in type 1 AIP,may play a permissive role in creating a favorable immunological environment for pancreatic carcinogenesis,in addition to the immunosuppressive therapies that can be used in these patients.

关 键 词：Autoimmune pancreatitis Chronic pancreatitis Pancreatic cancer Immunoglobulin G4-related disease Epidemiology IMMUNOLOGY BASOPHILS MACROPHAGES Th2 cells Systemic lupus erythematosus 

分 类 号：R576[医药卫生—消化系统] R735.9[医药卫生—内科学]