Epigenetic control on cell fate choice in neural stem cells  

作　　者：Xiao-Ling Hu Yuping Wang Qin Shen 

机构地区：[1]Center for Stem Cell Biology and Regenerative Medicine,School of Medicine,Tsinghua Center for Life Sciences,Tsinghua University,Beijing 100084,China [2]Department of Pharmacy,Tianjin Children’s Hospital,Tianjin 300074,China

出　　处：《Protein & Cell》2012年第4期278-290,共13页蛋白质与细胞（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(Grant No.2012CB966701);the Ministry of Science and Technology of the People’s Republic of China.

摘　　要：Derived from neural stem cells(NSCs)and progenitor cells originated from the neuroectoderm,the nervous system presents an unprecedented degree of cellular diversity,interwoven to ensure correct connections for propagating information and responding to environ-mental cues.NSCs and progenitor cells must integrate cell-intrinsic programs and environmental cues to achieve production of appropriate types of neurons and glia at appropriate times and places during develop-ment.These developmental dynamics are reflected in changes in gene expression,which is regulated by transcription factors and at the epigenetic level.From early commitment of neural lineage to functional plas-ticity in terminal differentiated neurons,epigenetic regulation is involved in every step of neural develop-ment.Here we focus on the recent advance in our un-derstanding of epigenetic regulation on orderly genera-tion of diverse neural cell types in the mammalian nervous system,an important aspect of neural devel-opment and regenerative medicine.

关 键 词：neural stem cells(NSCs) epigenetic regu-lation NEUROGENESIS GLIOGENESIS radial glial cell cerebral cortex subventricular zone(SVZ) DNA methylation histone modification 

分 类 号：R73[医药卫生—肿瘤]