supported by the Ministry of Science and Technology of China(STI2030-2021ZD0202300);the National Natural Science Foundation of China(32070971,32100768,32200776,and 32200792);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX01)。
Human’s robust cognitive abilities,including creativity and language,are made possible,at least in large part,by evolutionary changes made to the cerebral cortex.This paper reviews the biology and evolution of mammal...
supported by the Ministry of Science and Technology of China (STI2030-2021ZD0202300);National Natural Science Foundation of China (NSFC 31820103006,32070971,32100768,32200776,and 32200792);Shanghai Municipal Science and Technology Major Project (No.2018SHZDZX01);ZJ Lab,and Shanghai Center for Brain Science and Brain-Inspired Technology.
The seat of human intelligence is the human cerebral cortex,which is responsible for our exceptional cognitive abilities.Identifying principles that lead to the development of the large-sized human cerebral cortex wil...
the Ministry of Education,Science and Technological Development of the Republic of Serbia(Agreement number 451-03-9/2021-14/200042,to MiS,DSN,MM,DD and MaS);the Serbian Academy of Sciences and Arts(Grant number F24,to MiS(PI),MM,DD and MaS)。
Precise tuning of gene expression,accomplished by regulato ry networks of transcription factors,epigenetic modifiers,and microRNAs,is crucial for the proper neural development and function of the brain cells.The SOX t...
supported by grants from the MICINN-ISCⅢ(PI-10/00291 and MPY1412/09);MINECO(SAF2015-71140-R);Comunidad de Madrid(NEUROSTEMCM consortium; S2010/BMD-2336)(all to IL)
Although amyloid-β peptide is considered neurotoxic, it may mediate several physiological processes during embryonic development and in the adult brain. The pathological function of amyloid-β peptide has been extens...
There is great interest in the regenerative potential of the neural stem cells and progenitors that populate the subventricular zone(SVZ). However, a comprehensive understanding of SVZ cell responses to brain injuri...
supported by the National Natural Science Foundation of China,No.30800322;Shanghai Pujiang Program,No.08PJ1401300;Shanghai Leading Academic Discipline Project,No.B111;Ministry of Education Research Fund for New Teachers in Doctoral Program of Higher Educational Institutes,No.200802461050;National Basic Research Program of China(973 Program),No.2011CB503703;Ministry of Education Start Fund to Returned Overseas Scholars;Zhuo Xue Program of Fudan University
The multiple-layer structure of the cerebral cortex is important for its functions. Such a structure is generated based on the proliferation and differentiation of neural stem/progenitor cells. Notch functions as a mo...
supported by grants from the National Natural Science Foundation of China(Grant No.2012CB966701);the Ministry of Science and Technology of the People’s Republic of China.
Derived from neural stem cells(NSCs)and progenitor cells originated from the neuroectoderm,the nervous system presents an unprecedented degree of cellular diversity,interwoven to ensure correct connections for propaga...
This work was supported by the grant of National Natural Science Foundation of China (No. 30470598).
Objective To investigate the cell proliferation and differentiation in the developing brain of mouse. Methods C57/BL6 mice were divided into 3 groups at random. Bromodeoxyuridine (BrdU) was injected into the brains ...