Ligustrazine Attenuates Hyperhomocysteinemia-induced Alzheimer-like Pathologies in Rats  

作　　者：Qing ZHANG Jing WANG Liang ZHU Shi-jie JIANG Juan LIU Lin-xiao WANG Xi-hu QIN 

机构地区：[1]Laboratory of Neurological Diseases,the Afiliated Changzhou No.2 People's Hospital of Nanjing Medical University,Changzhou 213003,China [2]Department of Pediatrics,the Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University,Changzhou 213003,China [3]Department of Anesthesiology,the Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University,Changhow 213003,China [4]Department of Orthopedics,the Affliated Changzhou No.2 People's Hospital of Nanjing Medical University,Changehou 213003,China [5]Department of Endocrinology,the Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University,Changzhou 213003,China [6]Department of General Surgery,the Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University,Changzhou 213000,China

出　　处：《Current Medical Science》2021年第3期548-554,共7页当代医学科学（英文）

基　　金：grants from Changzhou Sci&Tech Program(No.CJ20190063,No.CJ20200090);Young Talent Development Plan of Changzhou Health Commission(No.CZQM2020078,and No.CZQM2020063);China Postdoctoral Science Foundation(No.2020M670012ZX);National Natural Science Foundation of China(No.81803498);Jiangsu Planned Projects for Postdoctoral Research Funds(No.2019K157);"Mass Entrepreneurship and Innovation Plan"of Jiangsu Province(No.QT201919).

摘　　要：Ligustrazine,an alkaloid extracted from the traditional Chinese herbal medicine Ligusticum Chuanxiong Hort,has been clinically applied to treat the cerebrovascular diseases.Hyperhomocystcincmia(Hhcy)is an independent risk factor for Alzheimer's disease(AD).Memory deficits can be caused by Hhcy via pathologies of Aβ-like tau and amyloid-β(Aβ)in the hippocampus.Here,we investigated whether homocysteine(Hey)can induce Aβ-like pathologies and the effects of ligustrazine on these pathologies.The Hey rat model was constructed by 14-day Hey injection via vena caudalis,and rats were treated with daily intragastric administration of ligustrazine at the same time.We found that the pathologies of tau and Aβ were induced by Hey in the hippocampus,while the Hcy-induced tau hyperphosphorylation and Aβ accumulation could be markedly attenuated by simultaneous ligustrazine treatment.Our data demonstrate that ligustrazine may be used as a promising neuroprotective agent to treat the Hcy-induced Aβ-like pathologies.

关 键 词：Alzheimer's disease LIGUSTRAZINE HYPERHOMOCYSTEINEMIA phosphorylated tau cognitive impairment 

分 类 号：R74[医药卫生—神经病学与精神病学]