Colocalization of dopamine receptors in BDNF-expressing peptidergic neurons in the rat paraventricular nucleus  

作　　者：Wang Zhiyong Zhou Li Zhang Yang Lian Hui Li Yong 

机构地区：[1]Department of Human Anatomy,Xinxiang Medical University,Xinxiang 453003,China

出　　处：《解剖学杂志》2021年第S01期76-76,共1页Chinese Journal of Anatomy

摘　　要：Brain derived neurotrophic factor(BDNF)in the paraventricular nucleus of the hypothalamus(PVN)can regulate food intake and energy expenditure.However,the regulatory mediator of BDNF positive neurons in the PVN remains unclear.Recently,widespread expression of the dopamine D1 receptor(DRD1)and D2 receptor(DRD2)has been observed in PVN neurons.We hypothesized that dopamine receptors(DRs)are also expressed in BDNF-positive neurons and mediate the function of BDNF in the PVN.Using multiple immunofluorescence assays combined with confocal microscopy,we found that BDNF immunoreactive(IR)neurons were widely distributed throughout the PVN in both the magnocellular and parvocellular regions.The BDNF protein was mainly expressed in the somas of neurons.The distribution of DR-IR neurons exhibited a pattern similar to that of BDNF.Nearly all DRD1 and DRD2 expression occurred within BDNF-IR neurons.

关 键 词：DOPAMINE INTAKE HYPOTHALAMUS 

分 类 号：R74[医药卫生—神经病学与精神病学]