LAMP2 is involved in estrogenic deficiency induced spatial memory impairment through autophagy-AB pathway  

作　　者：Cai Xiaoxia Lan Zhen Meng Zhaoyou Zhang Jiqiang Liu Yan 

机构地区：[1]Department of Neurobiology,Armny Medical University,Chongqing 400038,China [2]School of Life Sciences,Southwest University

出　　处：《解剖学杂志》2021年第S01期84-84,共1页Chinese Journal of Anatomy

摘　　要：LAMP2(lysosome associated membrane glycoprotein 2)is an important autophagy protein but its role in estrogenic regulation on spatial learning and memory remains unclear.In this study,we first infused aromatase(estrogen synthase)-specific RNA interference AAV into the hippocampus of mice,label-free quantitative proteomics analysis revealed that LAMP2 was the most significantly upregulated protein.This upregulation was further proved with RT-PCR,WB,IHC in ovariectomy(OVX)mice.Then,LAMP2-overexpressing(oLAMP2)and RNA interference(shLAMP2)virus vectors were injected into the hippocampus of OVX mice,respectively.

关 键 词：LAMP2 ESTROGEN IMPAIRMENT 

分 类 号：R73[医药卫生—肿瘤]