Cutaneous hypersensitivity as an indicator of visceral inflammation via C-nociceptor's axon bifurcation  

作　　者：Fang Yehong Han Shu Li Xiaorue Xie Yikuan Zhu Bing Gao Xinyan Ma Chao 

机构地区：[1]Institute of Basic Medical Sciences,Department of Human Anatomy,Histology and Embryology,Neuroscience Center,Chinese Academy of Medical Sciences,School of Basic Medicine,Peking Union Medical College,Beijing 100005,China [2]Department of Physiology,Institute of Acupuncture and Moxibustion,Academy of Chinese Medical Sciences

出　　处：《解剖学杂志》2021年第S01期136-136,共1页Chinese Journal of Anatomy

摘　　要：Pain on the body surface might accompany disorders in the deep tissue or internal organ.However,the anatomical and physiological mechanism is obscure.Here,we provided direct evidences of axon bifurcation in primary C-nociceptive neurons that innervate both the skin and a visceral organ.Double-labeled dorsal root ganglion(RG)neurons and Evans blue extravasation were observed in 3 types of chemo-induced visceral inflammation(colitis,urocystitis and acute gastritis)rat models.In the rat model of colitis,mechanical hypersensitivity and spontaneous activities were recorded in vivo from double-labeled C nociceptive neurons in S1 or L6 DRG.These neurons showed significantly enhanced responses to both somatic stimulation and colorectal distension.Our findings suggest that axon branching of C-noceptors may contribute to cutaneous hypersensitivity in visceral inflammation.Cutaneous hypersensitivity on certain locations of body surface might serve as an indicator of pathological conditions in the corresponding visceral organ.

关 键 词：VISCERAL INFLAMMATION HYPERSENSITIVITY 

分 类 号：R57[医药卫生—消化系统]