Cancer cell reprogramming:a promising therapy converting malignancy to benignity  

作　　者：Lanqi Gong Qian Yan Yu Zhang Xiaona Fang Beilei Liu Xinyuan Guan 

机构地区：[1]Department of Clinical Oncology,The University of Hong Kong,Hong Kong 999077,P.R.China [2]State Key Laboratory for Liver Research,The University of Hong Kong,Hong Kong 999077,P.R.China

出　　处：《Cancer Communications》2019年第1期434-446,共13页癌症通讯（英文）

摘　　要：In the past decade, remarkable progress has been made in reprogramming terminally differentiated somatic cells and cancer cells into induced pluripotent cells and cancer cells with benign phenotypes. Recent studies have explored various approaches to induce reprogramming from one cell type to another, including lineage-specific transcription factors-, combinatorial small molecules-, microRNAs- and embryonic microenvironment-derived exosome-mediated reprogramming. These reprogramming approaches have been proven to be technically feasible and versatile to enable re-activation of sequestered epigenetic regions, thus driving fate decisions of differentiated cells. One of the significant utilities of cancer cell reprogramming is the therapeutic potential of retrieving normal cell functions from various malignancies. However, there are several major obstacles to overcome in cancer cell reprogramming before clinical translation, including characterization of reprogramming mechanisms, improvement of reprogramming efficiency and safety, and development of delivery methods. Recently, several insights in reprogramming mecha-nism have been proposed, and determining progress has been achieved to promote reprogramming efficiency and feasibility, allowing it to emerge as a promising therapy against cancer in the near future. This review aims to discuss recent applications in cancer cell reprogramming, with a focus on the clinical significance and limitations of different reprogramming approaches, while summarizing vital roles played by transcription factors, small molecules, microR-NAs and exosomes during the reprogramming process.

关 键 词：Cancer cell reprogramming Transcription factor Small molecule MicroRNA EXOSOME MALIGNANCY BENIGN PLURIPOTENCY Cancer stem cell Induced pluripotent stem cell 

分 类 号：R73[医药卫生—肿瘤]