Nuclear glycogenolysis modulates histone acetylation:a novel mechanism of epigenetic regulation in cancer  

作　　者：Xifeng Dong 

机构地区：[1]Department of Hematology,General Hospital,Tianjin Medical University,Tianjin 300052,P.R.China

出　　处：《Cancer Communications》2019年第1期618-619,共2页癌症通讯（英文）

基　　金：This project is supported by Project of Tianjin Municipal Education Commission(No.20140118).

摘　　要：Cancer cells,as compared to normal cells,have their own metabolic alterations[1]which are essential for their survival and proliferation as they have higher energy production[2],maintenance for redox potential[3],and anabolic pathway induction[4].Thus,metabolic repro-gramming has been considered as a potential therapeu-tic target of cancer.In recent years,several studies have shown evidences that metabolic reprogramming is regu-lated by the genetic events of cancer cells.However,as the metabolites of the cancer cells also simultaneously affect epigenetic events,these make cancer cells depend-ent on certain metabolic-related substances,such as lipids and glutamine[5].

关 键 词：EPIGENETIC CANCER alterations 

分 类 号：R73[医药卫生—肿瘤]