The role of immune cells in obesogenic memory  

作　　者：Minli Sun Shang Zheng Xiang Gao Zhaoyu Lin 

机构地区：[1]MOE Key Laboratory of Model Animals for Disease Study,Model Animal Research Center,State Key Laboratory of Pharmaceutical Biotechnology,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing University,210061,Nanjing,China

出　　处：《Cellular & Molecular Immunology》2020年第8期884-886,共3页中国免疫学杂志（英文版）

基　　金：This work was supported by the Ministry of Science and Technology of China(grant 2018YFA0801100);the National Natural Science Foundation of China(grant 31772550).

摘　　要：Obesity is a serious chronic disease and worldwide public health problem.According to data from the World Health Organization(WHO),more than 650 million adults in the world were obese and three times more individuals were overweight in 2016.Obesity is associated with type II diabetes,hepatic steatosis,cardiovascular diseases,systemic chronic inflammation,and at least 13 types of cancer.Unfortunately,few effective remedies are available for obesity.The major problem is that most patients suffer from weight regain 2–3 years after obesity treatments,such as obesity drugs,lifestyle interventions(including exercise,diet restrictions,and diet modification),and bariatric surgery.Along with weight regain,most of the initial beneficial changes in metabolomic and transcriptomic profiles dissipate,including insulin sensitivity,the level of adipokines and blood cholesterol.This phenomenon has been defined as“obesogenic memory”.1,2 Obesogenic memory causes repeated weight loss and gain along with obesity therapy,which is called“weight cycling”,leading to a worse healthy status than would result from simple obesity.3,4.

关 键 词：OBESITY DRUGS INFLAMMATION 

分 类 号：R392[医药卫生—免疫学]