Delving into the recent advancements of spinal cord injury treatment: a review of recent progress  

作　　者：Joseph A.Flack Krishna Deo Sharma Jennifer Yanhua Xie 

机构地区：[1]Department of Basic Sciences,New York Institute of Technology College of Osteopathic Medicine at Arkansas State University,Jonesboro,AR,USA [2]Department of Biological Sciences and Arkansas Biosciences Institute,Arkansas State University,Jonesboro,AR,USA

出　　处：《Neural Regeneration Research》2022年第2期283-291,共9页中国神经再生研究（英文版）

摘　　要：Spinal cord injury(SCI) research is a very complex field lending to why reviews of SCI literatures can be beneficial to current and future researchers. This review focuses on recent articles regarding potential modalities for the treatment and management of SCI. The modalities were broken down into four categories: neuroprotectionpharmacologic, neuroprotection-non-pharmacologic, neuroregeneration-pharmacologic, neuroregeneration-non-pharmacologic. Peer-reviewed articles were found using Pub Med with search terms: "spinal cord injury", "spinal cord injury neuroregeneration", "olfactory ensheathing cells spinal cord injury", "rho-rock inhibitors spinal cord injury", "neural stem cell", "scaffold", "neural stem cell transplantation", "exosomes and SCI", "epidural stimulation SCI", "brain-computer interfaces and SCI". Most recent articles spanning two years were chosen for their relevance to the categories of SCI management and treatment. There has been a plethora of pre-clinical studies completed with their results being difficult to replicate in clinical studies. Therefore, scientists should focus on understanding and applying the results of previous research to develop more efficacious preclinical studies and clinical trials.

关 键 词：brain-computer interface epidural stimulation EXOSOMES NEUROPROTECTION NEUROREGENERATION scaffolds spinal cord injury management stem cells transplantation 

分 类 号：R651.2[医药卫生—外科学]