γ-tubulin as a signal-transducing molecule and meshwork with therapeutic potential  

作　　者：Maria Alvarado-Kristensson 

机构地区：[1]Molecular Pathology,DepartmentofTranslationalMedicine,LundUniversity,SkåneUniversityHospital,Malmö20502,Sweden

出　　处：《Signal Transduction and Targeted Therapy》2018年第1期90-95,共6页信号转导与靶向治疗（英文）

基　　金：The work described was funded in part by the Swedish Cancer Society(CAN 2016/3669);Skane University Hospital in MalmoCancer Research Fund(20151209);the Swedish Childhood Cancer Foundation(PR2016-0084),and the Crafoordska Foundation(20170530).

摘　　要：Knowledge ofγ-tubulin is increasing with regard to the cellular functions of this protein beyond its participation in microtubule nucleation.γ-Tubulin expression is altered in various malignancies,and changes in the TUBG1 gene have been found in patients suffering from brain malformations.This review recapitulates the known functions ofγ-tubulin in cellular homeostasis and discusses the possible influence of the protein on disease development and cancer.

关 键 词：HOMEOSTASIS cancer. THERAPEUTIC 

分 类 号：R73[医药卫生—肿瘤]