Emerging insights into HAUSP (USP7) in physiology, cancerand other diseases  

作　　者：Seemana Bhattacharya Dipankar Chakraborty Malini Basu Mrinal K Ghosh 

机构地区：[1]Signal Transduction in Cancer and Stem Cells Laboratory,Division of Cancer Biology and Inflammatory Disorder,Council of Scientific and Industrial Research-Indian Institute of Chemical Biology(CSIR-IICB),4 Raja S.C.Mullick Road,Kolkata-700032 and CN-06,Sector-V,Salt Lake,Kolkata 700091,India [2]Department of Microbiology,Barrackpore Rastraguru Surendranath College,6 Riverside Road and 85 Middle Road,Barrackpore,Kolkata 700120,India

出　　处：《Signal Transduction and Targeted Therapy》2018年第1期162-173,共12页信号转导与靶向治疗（英文）

基　　金：This work was supported by grants received from Council of Scientific and Industrial Research(CSIR),DST(DST-Nanomission-SR/NM/NS-1058/2015);DBT(Bio-cluster,Kolkata),Govt.of India.

摘　　要：Herpesvirus-associated ubiquitin-specific protease(HAUSP)is a USP family deubiquitinase.HAUSP is a protein of immense biological importance as it is involved in several cellular processes,including host-virus interactions,oncogenesis and tumor suppression,DNA damage and repair processes,DNA dynamics and epigenetic modulations,regulation of gene expression and protein function,spatio-temporal distribution,and immune functions.Since its discovery in the late 1990s as a protein interacting with a herpes virus regulatory protein,extensive studies have assessed its complex roles in p53-MDM2-related networks,identified numerous additional interacting partners,and elucidated the different roles of HAUSP in the context of cancer,development,and metabolic and neurological pathologies.Recent analyses have provided new insights into its biochemical and functional dynamics.In this review,we provide a comprehensive account of our current knowledge about emerging insights into HAUSP in physiology and diseases,which shed light on fundamental biological questions and promise to provide a potential target for therapeutic intervention.

关 键 词：DISEASES HAUSP INSIGHT 

分 类 号：R73[医药卫生—肿瘤]